METHODS FOR DEGRADING MUTAGENS

降解诱变剂的方法

• 批准号: 04557109
• 负责人: HAYATSU Hikoya
• 金额: $ 11.26万
• 依托单位: OKAYAMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04557109/
• 关键词: MUTAGEN; DEGRADATION; Fe-OCTACARBOXYPHTHALOCYANINE; RESIN BEARING METALLOPORPHYRIN; CHLOROPHYLLIN; HETEROCYCLIC AMINE; ポルフィリン担持樹脂; 吸着; グリーンレーヨン; Fe^<3+>-オクタカルボキシルフタロシアニン; Trp-p-2; cigarette smoke condensate; 金属ポルフィリン; ペルオキシダーゼ; 酸化的分解

1) Some of heterocyclic amines (Trp-P-1, Trp-P-2 and 2-amino-alpha-carboline) were degraded by the action of Fe-octacarboxyphthalocyanine-rayon(Fe-ocpc-rayon) in aqueous solutions. The presence of hydrogen peroxide in the solutions accelerated the degradation. Mutagens extracted from tabacco smoke also underwent the degradation by the Fe-ocpc-rayon.2) IQ was converted to red colored dimer by the action of a resin bearing Mn- or Fe-tetrakis (sulfonyl) porphine ligand in the presence of hydrogen peroxide.3) Hemin and chlorophyllin stimulated the degradation of benzo (a) pyrene-7,8-diol-9,10 epoxide, a potent carcinogenic metabolite of benzo(a)pyrene.

1）在水溶液中，一些杂环胺（TRP-P-1，TRP-P-2和2-氨基 - 钙 - 碳酸酯）被Fe- o-Octacarboxyphathalocyanine-rayon（Fe-OCPC-Rayon）降解。溶液中过氧化氢的存在加速了降解。从Tabacco烟中提取的诱变还通过Fe-OCPC-rayon进行降解。2）IQ通过在氢氧化物的存在下将含Mn-或fe-tetrakis（Sulfonyl）卟啉的树脂轴承（Sulfonyl）卟啉配体的树脂粘合剂（氢氧化物）的作用转化为红色二聚体。 pyrene-7,8-二醇-9,10环氧，这是一种有效的苯并（a）pyrene的致癌代谢产物。

项目成果

H. Hayatsu: "Dietary inhibitors against mutagenesis and carcinogenesis." Antimutagenesis and Anticarcinogenesis Mechanisms III. 387-418 (1993)

H. Hayatsu：“抗诱变和致癌的饮食抑制剂。”

H. Hayatsu: "Cellulose bearing covalently linked copper phthalocyanine trisulfonate as an adsorbent selective for polycyclic compounds." J. Chromatography. 497. 37-56 (1992)

H. Hayatsu：“带有共价连接的铜酞菁三磺酸盐的纤维素作为多环化合物的选择性吸附剂。”

H. Hayatsu: "Porphyrins as potential inhibitors against exposure to carcinogens and mutagens." Mutation Res.290. 79-85 (1993)

H. Hayatsu：“卟啉是接触致癌物和诱变剂的潜在抑制剂。”

H.HAYATSU: "Cellulose bearing covalently linked copper phthalocyanine trisulfonate as an adsorbent selective for polycyclic compounds." J.Chromatography. 497. 37-56 (1992)

H.HAYATSU：“带有共价连接的铜酞菁三磺酸盐的纤维素作为多环化合物的选择性吸附剂。”

T. Negishi: "Inhibitory activity of chlorophyllin on the mutagenicity of carcinogens in Drosophila." Cancer Letters. 83. 157-164 (1994)

T. Negishi：“叶绿素对果蝇致癌物致突变性的抑制活性。”