Developmental Research for New Medicines Based on Carbohydrate-cell Recognition

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We have examined the recognition specificity of sialooligosaccharides by influenza virus and leukocyte cell adhesion molecules (selectin family) at the molecular level. As a results, it has been shown that 1) sialyl paragloboside is one of the best substrate for influenza virus recognition, and 2) both sialyl-Lewis X and sialyl-Lewis A can be well recognized by all selectins. It was also found that sulfo-Lewis X and sulfo-Lewis A function as the selectin ligands with the equal or more afinity than the corresponding sialyl derivatives.Based on these results, a variety of novel oligosaccharides containing 1-deoxynojirimycin have been synthesized as the inhibitors of virus infection and selectin binding. Some of the N-alkyl-1-deoxynojirimycin-containing sialyl-and sulfo-Lewis X and -Lewis A epitope analogs have been found to be potent anti-inflammatory agents by using the animal models. A wide therapeutic application of these compounds is now in progress.