FUNDAMENTAL AND PRACTICAL STUDIES OF DERMAL PATCH ANESTHESIA

(1)我们开发了一种经皮适用的10%利多卡因凝胶，其中3%甘次酸一邻苯二甲酸二钠（GAMPh 2Na）作为吸收促进剂。(2) 3% gamph2na作为吸收促进剂的作用在双盲人体研究中得到证实。(3) 65.5%的成人患者和82.4%的儿童患者在应用约60 min后无痛进行静脉插管。(4)健康志愿者经皮应用0.3g利多卡因凝胶后血药浓度小于0.01mu/ml。5)利多卡因凝胶贴片与EMLA乳膏贴片具有相同或稍强的局部皮肤镇痛作用。6)利多卡因凝胶治疗有助于减轻带状疱疹急性期或亚急性期的疼痛。7)除增强经皮吸收外，gamph2na还抑制经皮吸收利多卡因引起的皮肤血管舒张。8)皮肤预处理，如胶带剥离或苯清洗，缩短了皮贴麻醉的潜伏期。9)除经细胞主根外，一些经皮应用的凝胶通过附属根如分泌汗腺和毛囊皮脂腺深入皮肤。

(1) We have developed a transdermally applicable 10% lidocaine gel with 3% glycyrrhetinic acid monohemiphthalate disodium (GAMPh 2Na) as an absorption promoter.(2) The effect of 3% GAMPh 2Na as an absorption promoter was confirmed in a double blind human study.(3) Venous cannulation was carried out without pain in 65.5% of the adult patients and 82.4% of children after about 60 min of application.(4) The blood concentration of lidocaine after transdermal application of 0.3g of the gel to healthy volunteers was less than 0.01mu/ml.5) The lidocaine gel patch was as potent or slightly more potent in producing local skin analgesia as the EMLA cream patch.6) The lidocaine gel treatment was useful for reduction of pain associated with acute or subacute phase of herpes zoster.7) Besides enhancement of transdermal absorption, GAMPh 2Na suppressed cutaneous vasodilation induced by transdermally absorped lidocaine.8) Skin pretreatments, such as stripping with gum tape or cleaning with benzene, shortened the latency time of the dermal patch anesthesia.9) In addition to the transcellular main roots, some of the transcutaneously applied gel penetrated deeply into the skin through the appendageal roots such as the eccrine sweat glands and the pilo-sebaceous glands.