FUNDAMENTAL AND PRACTICAL STUDIES OF DERMAL PATCH ANESTHESIA

皮肤贴片麻醉的基础和实践研究

• 批准号: 05557069
• 负责人: KANO Tatsuhiko
• 金额: $ 2.43万
• 依托单位: KUMAMOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05557069/
• 关键词: DERMAL PATCH ANESTHESIA; ABSORPTION PROMOTER; LIDOCAINE GEL; 貼付皮膚麻酔

(1) We have developed a transdermally applicable 10% lidocaine gel with 3% glycyrrhetinic acid monohemiphthalate disodium (GAMPh 2Na) as an absorption promoter.(2) The effect of 3% GAMPh 2Na as an absorption promoter was confirmed in a double blind human study.(3) Venous cannulation was carried out without pain in 65.5% of the adult patients and 82.4% of children after about 60 min of application.(4) The blood concentration of lidocaine after transdermal application of 0.3g of the gel to healthy volunteers was less than 0.01mu/ml.5) The lidocaine gel patch was as potent or slightly more potent in producing local skin analgesia as the EMLA cream patch.6) The lidocaine gel treatment was useful for reduction of pain associated with acute or subacute phase of herpes zoster.7) Besides enhancement of transdermal absorption, GAMPh 2Na suppressed cutaneous vasodilation induced by transdermally absorped lidocaine.8) Skin pretreatments, such as stripping with gum tape or cleaning with benzene, shortened the latency time of the dermal patch anesthesia.9) In addition to the transcellular main roots, some of the transcutaneously applied gel penetrated deeply into the skin through the appendageal roots such as the eccrine sweat glands and the pilo-sebaceous glands.

(1)用3%甘草次酸邻苯二甲酸二钠(GAMPh2Na)作为吸收促进剂，研制了一种透皮用的10%利多卡因凝胶。(2)3%GAMPh2Na作为吸收促进剂在人体双盲研究中得到证实。(3)65.5%的成人患者和82.4%的儿童患者在使用约60min后无痛地进行静脉插管。(4)健康志愿者经皮给药0.3g利多卡因凝胶后的血药浓度小于0.01mU/ml5)在产生局部皮肤止痛方面，利多卡因凝胶贴片与EMLA乳膏贴片一样有效或略强。6)利多卡因凝胶疗法有助于减轻与带状疱疹急性期或亚急性期相关的疼痛。7)除了促进经皮吸收外，GAMPh2Na可抑制利多卡因经皮吸收引起的皮肤血管扩张。8)皮肤预处理，如胶带剥离或苯清洁，缩短了真皮贴片麻醉的潜伏期。9)除跨细胞主根外，一些经皮肤应用的凝胶通过附属器根部深入皮肤，如外分泌汗腺和皮脂腺。

项目成果

Kano T,etal: "Evaluation of the penetration depth of transdermally applied 3% GAMHPh 10%" Iidocaine gel in man .J.Anesth.7. 21-26 (1993)

Kano％20T，等人：％20“评估％20of％20the％20渗透％20深度％20of％20透皮％20应用％203％％20GAMHPh％2010％”％20利多卡因％20gel％​​20in％20man％20.J.Anesth.7。

Sakamoto M,Kano T.Sadanaga M,Morioka T,Mishima M,Nakano M: "Dermal patch anesthesia : Comparison of 3% GAMHPh-10% lidocaine gel and EMLA cream." Anaesthesia. 48. 390-392 (1993)

坂本%20M、鹿野%20T.定永%20M、盛冈%20T、三岛%20M、中野%20M:%20"真皮%20贴片%20麻醉%20:%20比较%20of%203%%20GAMHPh-10%%20利多卡因%

Nakamura M,Kano T,Sakamoto M,Shimoda O,Morioka T,Mishima M,Nakano M: "Dermal patch anesthesia with 10% lidocaine gel containing glycyrrhetinic acid monohemiphthalate disodium as an absorption promoter." Kumamoto Med J. 44. 111-122 (1993)

中村%20M、鹿野%20T、坂本%20M、下田%20O、盛冈%20T、三岛%20M、中野%20M:%20"真皮%20贴剂%20麻醉%20含%2010%%20利多卡因%20凝胶%20含%20甘草次%

Kano T,et al: "Evaluation of the plnetration depth of transdermally applied 3% GAμHph-10% lidocainl gel in man" J Anesth. 7. 21-26 (1993)

Kano T 等人：“经皮应用 3% GAμHph-10% 利多卡因凝胶在人体中的渗透深度的评估”J Anesth. 7. 21-26 (1993)

Kano T,Nakamura M,Hashiguchi A,Masuda K,Morioka T,Mishima M,Nakano M: "Evaluation of the penetration depth of transdermally applied 3% GAMHPh-10% lidocaine gel in man" J Anesth. 7. 21-26 (1993)

卡诺%20T、中村%20M、桥口%20A、增田%20K、盛冈%20T、三岛%20M、中野%20M:%20"评价%20of%20%20渗透%20深度%20of%20透皮%20涂抹%203%%