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Biorhythm disorder and homeostasis maintenance in the perioperative period

围术期生物节律紊乱与体内平衡维持

基本信息

批准号：
13470329
负责人：
KANO Tatsuhiko
金额：
$ 6.14万
依托单位：
Kurume University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2003
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13470329/
关键词：
Periodic Fluctuation Cardiovascular System Skin Capillary CRPS Hyperhidrosis Ischemic Encephalopathy Sympathetic Nerve Partial Blockade 周期的動揺 RSD

项目摘要

1. Observations under General Anesthesia(1) Monitoring of Spinal Cord Function ; The combination of motor evoked potentials by transcranial electrostimulation of the brain and spinal cord evoked potentials by epidural electrostimulation of the spinal cord provided reliable monitoring of the spinal function during the graft replacement of thoracoabdominal aortic aneurysm. Ultrasound beam perpendicular to the spinal cord through the intervertebral discs clearly visualized pulsating spinal canal contents.(2) Latent Ischemia of Vital Organs in Circulatory Arrest with Deep Hypothermia; Serum lactic acid increased in prolonged circulatory arrest over 45 min even under deep hypothermia less than 20℃, suggesting possible post-operative disfunction of the vital organs such as brain and kidney.2. Autonomic Nervous Function in Total Spinal BlockThe recovery process of the vagal nerve and subsequent thoracic sympathetic nerve were separately observed.3. Periodical Fluctuations of the Finger-tip Skin Capillary after Thoracic SympathectomyEndoscopic coagulation of the sympathetic chain was proved to be a partial block. Periodical fluctuations of the skin capillary was restored even with the palmar hyperhidrosis suspended.4. Periodical fluctuations of the Finger-tip Skin Capillary in Patients with CRPSPeriodical fluctuations of the finger-tip skin capillary differed in the stage of complex regional pain syndrome(CRPS). Those were enhanced in the early stage of CRPS.

1.全麻下观察（1）脊髓功能监测：经颅电刺激脑运动诱发电位和硬膜外电刺激脊髓诱发电位联合应用，可在胸腹主动脉瘤人工血管置换术中可靠地监测脊髓功能。垂直于脊髓的超声束穿过椎间盘清楚地显示了脉动的椎管内容物。(2)结论1.深低温停循环时重要器官的潜伏性缺血即使在低于20℃的深低温下，长时间停循环超过45 min时，血清乳酸也会升高，提示术后可能存在脑、肾等重要器官的功能障碍.全脊髓阻滞中自主神经功能的变化分别记录迷走神经和胸交感神经的恢复过程.胸交感神经切除术后指尖皮肤毛细血管的周期性波动内镜下交感神经链的凝固被证明是部分阻断。皮肤毛细血管的周期性波动得到恢复，即使手掌多汗暂停。复杂性区域疼痛综合征（CRPS）患者指尖皮肤毛细血管周期性波动在CRPS不同阶段，指尖皮肤毛细血管周期性波动不同。在CRPS的早期即有强化。