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Development of gnobotiotic mice for screening of efficiency of Probiotics

Development of gnobotiotic mice for screening of efficiency of Probiotics
开发用于筛选益生菌功效的侏儒小鼠
批准号:
05558103
负责人:
ITOH Kikuji
金额:
$7.55万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Developmental Scientific Research (B)
财政年份:
1993
资助国家:
日本
项目状态:
已结题
起止时间:
1993 至 1995

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中文摘要
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英文摘要
We attempted to produce pig-flora-associated mice (PFM) for screening of efficiency of probiotics. The composition of fecal microbiota and concentrations of fecal short chain fatty acids and putrefactive products were studied in pigs and PFM.Major components of fecal bacterial groups of pigs were able to colonize in the intestine of PFM,but the species of Bacteroidaceae and Streptococaceae were significantly different between pigs and PFM.Fecal putrefactive products in PFM were undetectable although concentrations of them in pigs were high level. Concentrations of the major components of SCFAs of PFM were similar to those of the inocula.
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会议论文
Hirayama, K., Itoh, K. 他: "Development of intestinol flora of Human-Flora-Assuciated(HFA) mice in the intestine of their offspring." Exp. Anim. 44. 219-222 (1995)
Hirayama, K., Itoh, K. 等人:“人类菌群相关 (HFA) 小鼠在其后代肠道中的肠道菌群的发育。”Exp Anim。
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Hara, H., Terada, T. 他: "Effect of tea Polyphenols on fecal flora and fecal metabolic products of pigs." J. Vet. Med. Sci,. 57. 45-49 (1995)
Hara, H., Terada, T. 等人:“茶多酚对猪粪便菌群和粪便代谢产物的影响”,J. Vet,57. 45-49 (1995)。
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Giacoboni,G.I.他: "Comparison of feca l Campylobacter in calves and cattle of different ages and areas in Japan" J.Vet.Mes.Sci. 55. 555-559 (1993)
Giacoboni, G.I. 等人:“日本不同年龄和地区的小牛和牛的粪便弯曲杆菌的比较”J.Vet.Mes.Sci. 55. 555-559 (1993)
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通讯作者:
Hirayama,K.他: "Effects of dietary supplements on the composition of fecal flora of human-flora-associated(HFA)mice." Bifidobacteria Microflora. 13. 1-7 (1994)
Hirayama, K. 等人:“膳食补充剂对人类菌群相关 (HFA) 小鼠粪便菌群组成的影响。双歧杆菌微生物区系”13. 1-7 (1994)。
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25
    Production of basic intestinal microflora for SPF mice using development of lesions of human desease modele mice as an indicator.
    • 批准号:
      18300138
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.23万
    • 财政年份:
      2006
    • 负责人:
      ITOH Kikuji
    • 依托单位:
    Development of monitaruin system for intestinal flora of experimental animals using FISH method
    • 批准号:
      14380379
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.54万
    • 财政年份:
      2002
    • 负责人:
      ITOH Kikuji
    • 依托单位:
    Study of control mechanisms of gene expression related to colorectal cancer by intestinal flora in rasH2 mice
    • 批准号:
      12480250
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.34万
    • 财政年份:
      2000
    • 负责人:
      ITOH Kikuji
    • 依托单位:
    Ecological study of Bacteroides species habored in the intestine of laboratory animals.
    • 批准号:
      04454576
    • 项目类别:
      Grant-in-Aid for General Scientific Research (B)
    • 资助金额:
      $4.35万
    • 财政年份:
      1992
    • 负责人:
      ITOH Kikuji
    • 依托单位:
    海外基金