Medical Scientific Research on Highlanders in Himalayas

喜马拉雅山高地人的医学科学研究

• 批准号: 05041107
• 负责人: KURIYAMA Takayuki
• 金额: $ 8.32万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05041107/
• 关键词: Hypoxia; High Altitude; Adaptation; Tuberculosis; Hodgkin Disease; EB virus; Gastric cancer; Lymphoma; Helicobacter pylori; Highlander; Tuberculosis; Mountain Sickness; Carotid body; Carotid Body; Respiratory Control; Living Environment

1. Respirato-physiological study in Nepal Himalayan. Study of altitude acclimatization mechanism of respiratory control was carried out in Nepal Khumbu area. Resting ventilation and SpO2s during breath holding test from end-expiratory lung volume and effect of oxygen on these parameters were studied at 1300m, 2827m, 3440m and 4430m. Analysis of relationships between these parameters and hypoxic ventilaotry response revealed that even after acclimatizing period increased hypoxic chemosensitivity was accompanied by hypoxic ventilatory depression which was markedly detected in acute hypobaric hypoxia study at sea level.2. Pathological study on EB virus related tumors in Nepal. Regional differences have been reported in a histological type of Hodgkin disease (HD) and frequency of EB virus related HD.24 cases of lymphoma and 54 cases of gastric cancer speciemens of the pathological department of Tribuban University Hospital and CMN Patan Hospital in Katmandu were studied immunologically and pathologically. 7 out of 8 HD and 1 out of 16 non-Hodgkin lymphoma cases revealed LMP-1 and EBER-1 ISH positive. In case of gastric cancer, only one out of 54 cases was a positive. Helicobacter Pylori infection was identified in 14 cases out of 38 low differentiated type and one case out of 2 mucous type. No case was positive in 13 high and intermediate differentiated types.3. Histological study on high-altitude animals. Histological study on alveolar structure of Yak (Bos grunnieens) grown up in Nepal Himalayan region and Tibetan plateau was performed. Optical microscopic study showed that the Yak have wider alveolar space and thinner alveolar wall, though elastic fibers in the wall were more clearly identified than that of human. Electron microscopic study showed fewer type II alveolar endothelial cell and more and larger Kohn's pores than rat. These modified configuration in alveolar structure is considered to be morphological adaptive response to long term hypoxia.

1.尼泊尔喜马拉雅山的呼吸生理学研究。在尼泊尔昆布地区进行了呼吸控制的高原习服机制研究。在海拔1300米、2827米、3440米和4430米四个海拔高度，观察了不同氧浓度对静息通气量、呼气末肺容积、屏气试验SpO 2s的影响。分析这些参数与低氧通气反应的关系发现，即使在适应期后，低氧化学敏感性的增加也伴随着低氧性抑制，这在海平面急性低压低氧研究中明显检测到.尼泊尔EB病毒相关肿瘤的病理学研究霍奇金病（HD）的组织学类型和EB病毒相关HD的发生率存在地区差异。对加德满都Tribuban大学医院和CMN Patan医院病理科的24例淋巴瘤和54例胃癌标本进行了免疫学和病理学研究。8例HD中7例LMP-1和16例非霍奇金淋巴瘤中1例EBER-1 ISH阳性。在胃癌病例中，54例中只有1例为阳性。38例低分化型中14例检出幽门螺杆菌感染，2例粘液型中1例检出幽门螺杆菌感染。13例高、中分化型无1例阳性.高原动物的组织学研究。对生长在尼泊尔喜马拉雅地区和青藏高原的牦牛肺泡结构进行了组织学研究。光学显微镜观察发现，牦牛肺泡腔较宽，肺泡壁较薄，但肺泡壁内弹性纤维较清晰。电镜观察显示肺泡Ⅱ型内皮细胞数量少，Kohn孔多且大。肺泡结构的这些改变被认为是对长期缺氧的形态学适应性反应。

项目成果

Y.Honda,A Masuda,T.Kobayashi,M.Tanaka,H Kimura,S.Masuyama T.Kuriyama: "Proceedings of the London Conference on Modeiliy and control of ventilation" Plenam Press, (1995)

Y.Honda、A Masuda、T.Kobayashi、M.Tanaka、H Kimura、S.Masuyama T.Kuriyama：“伦敦通风模式和控制会议记录”Plenam Press，（1995 年）

S.Masuyama, Y.Honda, T.Kuriyama et al.: "Preserved vagal tone and fractal property in HR variance in Sherpa" "Hypoxia and Brain" eds. By Sutton et al. Queen Printers Inc., Vermont. 330 (1995)

S.Masuyama、Y.Honda、T.Kuriyama 等人：“夏尔巴人 HR 方差中保留的迷走神经张力和分形特性”“缺氧与大脑”编辑。

A.Mikata et.al.: "Association of Epstein-Barr Virus with gastric carcinoma with lympoid stroma" Am.J.Pathol.143. 143. 1-8 (1993)

A.Mikata 等人：“Epstein-Barr 病毒与胃癌和淋巴基质的关联”Am.J.Pathol.143。

栗山喬之 他: "各種慢性肺疾患におけるCold Bressoor Testの肺循環動態へ及ぼす影響" 日本胸部疾患学会雑誌. 31. 206-213 (1993)

Takayuki Kuriyama 等人：“冷 Bressoor 试验对各种慢性肺部疾病的肺血流动力学的影响”日本胸科疾病学会杂志 31. 206-213 (1993)。

栗山喬之 他: "初感染結核に対する化学療法" 結核. 68. 21-28 (1993)

Takayuki Kuriyama 等人：“结核病原发感染的化疗”结核病。