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Development of High-Performance Polyurethane Biomaterials

高性能聚氨酯生物材料的开发

基本信息

批准号：
05044107
负责人：
KAJIYAMA Tisato
金额：
$ 2.88万
依托单位：
KYUSHU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1994
项目状态：
已结题

项目摘要

Since segmented liquid crystalline polyurethanes (LCPUEs) have a liquid crystalline hard segment, LCPUEs expected to show a unique behavior in mechanical and biomedical performances. The purpose of this study is to investigate the applicability of LCPUEs for biomedical field. Following subjects have been studied in 1993 and 1994.1) Synthesis and characterization of LCPUESegmented liquid crystalline polyurethanes (LCPUEs) with the hard segments composed of the mesogen 4,4'-bis (6-hydroxyhexoxy) biphenyl and toluene diisocyanate (TDI), and the soft segments composed of poly (tetramethylene oxide) (PTMO) with various molecular weight have been prepared. Differential scanning calorimetric and wide angle X-ray diffraction study revealed that the endotherm at 403K corresponding to the isotropization transition.2) Surface structure analysis of LCPUESince biomaterials have been used in an aqueous environment, a freeze-etch X-ray photoelectron spectroscopic technique has been developed. This te … More chnique revealed the surface enrichment of hydrophilic component at the water-solid interface.3) Evaluation of surface thermal molecular motion of LCPUESurface structure of LCPUEs was studied on the basis of X-ray photoelectric spectroscopy (XPS), and the atomic force microscopy (AFM). As-cast LCPUE showed the smooth flat surface with nanometer scale. Annealing of LCPUE at 378K induced the ordering of mesogenic hard segment. Annealing of LCPUE with PTMO (Mn=2000) showed the increase in surface roughness. The scanning viscoelasticity microscopic (SVM) measurement was carried out in order to confirm the presence of phase-spparated structure on the surface of LCPUE with PTMO (Mn=2000). SVM revealed that bump was mainly composed of rubbery PTMO phase. This characteristic surface morphology was formed due to the ordering of hard segment being accompanied the increase in conformational entropy of PTMO segments.4) Interaction between plasma protein and LCPUEThe interactions between plasma protein and microphase-separated surface have been studied on the basis of ATR-IR flow cell technique and AFM.AFM results revealed the domain recognized adsorption of plasma protein. Less

由于嵌段液晶聚氨酯（LCPUE）具有液晶硬段，LCPUE有望在机械和生物医学性能方面表现出独特的行为。本研究的目的是探讨LCPUE在生物医学领域的适用性。1993年和1994年进行了以下几个方面的研究：1）液晶聚氨酯的合成与表征制备了硬段由液晶基元4，4 ′-双（6-羟基己氧基）联苯和甲苯二异氰酸酯（TDI）组成，软段由不同分子量的聚四氢呋喃（PTMO）组成的嵌段液晶聚氨酯（LCPUE）。差示扫描量热和广角X射线衍射研究表明，在403 K处的吸热峰对应于各向同性转变。2）LCPUE的表面结构分析由于生物材料已经在水环境中使用，因此发展了冷冻蚀刻X射线光电子能谱技术。这个特 ...更多信息利用X射线光电子能谱（XPS）和原子力显微镜（AFM）研究了LCPUEs的表面结构。铸态LCPUE表面光滑平整，具有纳米尺度。在378 K退火LCPUE诱导了介晶硬段的有序化。用PTMO（Mn=2000）退火的LCPUE显示表面粗糙度增加。采用扫描粘弹性显微镜（SVM）测量了PTMO（Mn=2000）对LCPUE表面相分离结构的影响。支持向量机分析表明，凸点主要由橡胶状PTMO相组成。这种特征性的表面形貌是由于硬段有序化伴随着PTMO段构象熵的增加而形成的。4）血浆蛋白与LCPUE的相互作用基于ATR-IR流动池技术和AFM研究了血浆蛋白与微相分离表面的相互作用。少