Studies on Safety and Effectiveness of Dentin Pretreatment Agents, Pulp Capping Agents and Base Materials

牙本质预处理剂、盖髓剂及基材的安全性和有效性研究

• 批准号: 05304043
• 负责人: SHIMOKOBE Hirokata
• 金额: $ 14.91万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Co-operative Research (A)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05304043/
• 关键词: Dentin Pretreatment Material; Antibacterial Capping Agent; Base Cement; Dentin Primer; Phytic Acid; EDTA LaNa; Tannic Acid; Cytotoxity; 抗菌性覆髄剤; ベース材

1.A new cytotoxic test of dental materials on human neutrophils was established by determining the production of O_2^- and the release of LDH.The addition of collagen-combined BMP induces differentiation of bone marrow stromal cells into osteoblasts.(shimokobe, Matsui and Inoue)2.The antibacterial capping agent(alpha-TCP with mixed antibacterial drugs)effectively disinfected bacterially contaminated pulp tissue without destroying surrounding pulp tissue(Iwaku).3.The dentin priming by the aqueous solution of the ethylene glycol or 1,6-hexanediol was considered to be desirable because the contraction gap formation of the light activated resin compostite was prevented. And the possible side effect on the skin tissue by the methacrylate derivatives was avoided by using the diol solutions.(Hisamitsu)4.When the dentin surface was treated with chelating agent(phytic acid)and metallic ion(Sn^<2+>), shear bond strength of resin to dentin did not change after 1,000 thermo-cycled(Kohno and Sakamo … More to).5.Glass ionomer lining materials showed the strongest cellular growth of ten pulp capping materials tested which did not show any mutagenic potential using UMU-test kit(Aono).6.The dentin surface treated with La-containing conditioner showed higher hardness, better acid resistance and higher bond strength with resin bonding agent(Hara and Senda).7.Among three experimental penetrometers of Al, Cu or Ti for objective measuring of radiopacity of base cements, Ti-penetrometer revealed the best results(Fujii and Narikawa).8.Increased concentration of tannic acid and increased incubation times in the acid effectively decreased the dissolved amount of dentin collagen(Shintani).9.Not only calcium hydroxide but also alkyl salicylates influenced the antimicrobial activity of the set calcium hydroxide cements(Nagasawa).10.The grinding of tetracalcium phosphate(TTCP)increased the mcchanical strength of the cement based on polymethyl vinyl ether-maleic acid and TTCP,decreased its solubility, and accelerated the hydroxyapatite formation(Matsuya). Less

1.通过确定O_2^ - 的产生和LDH的释放，建立了对人类嗜中性粒细胞的新的细胞毒性测试。添加胶原蛋白兼有的BMP诱导骨髓骨髓细胞的分化，将骨骨髓细胞的分化成纤维细胞。药物）有效地消毒了细菌污染的果肉组织，而不会破坏周围的果肉组织（Iwaku）。3。乙烯乙二醇的水溶液或1,6-己糖苷的水溶液被认为是可取的，因为被认为是值得期望的，因为光活化果蛋白综合的缩写隙形成。 （hisamitsu）避免了甲基丙烯酸酯衍生物对皮肤组织的可能副作用。玻璃离子体衬里材料显示了测试的十块纸浆盖材料的强细胞生长，使用UMU检测试剂盒（AONO）没有显示任何诱变势。6。用含有LA的护发素处理的牙本质表面表现出更高的硬度，更好的酸性和用树脂键合剂（HARA和SENDA）的更高键强度。7。在Al，Cu或Ti的三个实验性穿透器中，用于客观测量碱水泥的放射性测量，Ti-Penetmeter显示了最佳结果（Fujii和Narikawa）。8。酸的浓度的浓度增加，酸在酸中有效减少了dentin Collagen collagen collagen collagen collagen（Shintani）的降低（shintani）。固定氢氧化钙胶结（长川）的抗菌活性。10。磷酸四钙的研磨（TTCP）提高了基于多甲基乙烯基乙烯基取纤维酸和TTCP的水泥的麦克键强度，可降低其溶解度，并降低其溶解度，并加入了盐水和加速度的形式。较少的

项目成果

C.Tani, et al: "Efficacy of Dentin Bonding Agents Combined with Self-etching Dentin Primers Containing Phenyl-P" Dent Mater J. 12. 219-224 (1994)

C.Tani 等人：“牙本质粘结剂与含有 Phenyl-P 的自酸蚀牙本质底漆相结合的功效”Dent Mater J. 12. 219-224 (1994)

Kunihiro Yoshiba: "Effects of Antibacterial Capping Agents on Dental Pulps of Monkeys Mechanically Exposed to Oral Microflora." Journal of Endodontics. 21(in press). (1995)

Kunihiro Yoshiba：“抗菌加盖剂对机械暴露于口腔微生物群的猴子牙髓的影响。”

薄井秀樹: "キレート化剤と金属イオンを組み合わせたプライマーの各種ボンディング剤への応用" 日本歯科保存学雑誌. 36. 1031-1053 (1993)

Hideki Usui：“结合螯合剂和金属离子的底漆在各种粘合剂中的应用”日本保守牙科杂志 36. 1031-1053 (1993)。

Kanamori K.: "Effect of Dentin Pretreatment with EDTA-La-Na on Resin-Dentin Bonding" Aichi-Gakuin Dental Science. 6. 17-23 (1993)

Kanamori K.：“EDTA-La-Na 牙本质预处理对树脂-牙本质粘合的影响”爱知学院牙科科学。

Yoko Matsuya: "Effect of abietic acid and poly(methyl methacrylate) on the dissolution process of zinc oxide-eugenol cement" Biomaterials. 15. 307-314 (1994)

Yoko Matsuya：“松香酸和聚甲基丙烯酸甲酯对氧化锌-丁子香酚水泥溶解过程的影响”生物材料。