GaAlAs Laser Therapy in Dentin Hypersensitivity and Histopathological Changes of the Dental Pulp Tissues

GaAlAs激光治疗牙本质过敏和牙髓组织的组织病理学变化

• 批准号: 61570906
• 负责人: SHIMOKOBE Hirokata
• 金额: $ 1.22万
• 依托单位: Hokkaido Univ.
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61570906/
• 关键词: Diode Laser; Dentin Hypersensitivity; 歯髄変化; レーザー; 知覚過敏; 象牙質; 半導体

Recent studies have shown the effects of diode laser irradiation in treatment for dentin hypersensitivities. However,the system of the effects still remains unsolved. The conditions and indications of irradiation in the diseases are, therefore, not defined in detail, which decreases clinical reliability of the laser therapy for pain.The study was designed to examine histopathological change of dental pulp tissue by laser irradiation to know the mechanism of the effects.Continuous irradiation at 30mW was performed for 60 and 90 seconds under direct contact of a probe to occlusal surface of the first molars of male Wistar rats by using Ga-Al-As diode laser(<lambda>: 830nm, Osada Electric Co.). The rats were sacrificed 2 weeks after irradiation and the pulp tissues were routinely examined histopathologically under light microscope. Clinical examination also done on the patients having hypersensitive dentinunder their consents.Experiments indicate ; 1) No differences were detected in histopathological appearance of pulp tissues between irradiated and non-irradiated groups in this study. Since loss of pain by laser irradiation may give some histological change to pulp tissue, ultratine structure investigation would find the changes in future. 2) In clinical experiment, of 61 cases, the findings showing remarkable effective, effective, and non-effective were 10(16%), 29(48%), and 22(36%) cases, respectively. Though the laser irradiation yielded immediate effect, pain returned in some cases. This uncertain clinical results suggested further study on informations of dentin hypersensitivity to get higher clinical reliability.

最近的研究表明，半导体激光照射治疗牙本质过敏症的效果。然而，系统的影响仍然没有解决。因此，没有详细定义疾病中辐照的条件和适应症，本研究采用30 mW的激光照射60和90 s，观察牙髓组织的组织病理学变化，探讨激光对牙髓组织的影响机制使用Ga-Al-As二极管激光器（<lambda>：830 nm，Osada Electric Co.），照射后2周处死大鼠，光镜下常规观察牙髓组织病理学变化。实验结果表明：1）照射组与非照射组牙髓组织的病理组织学改变无明显差异;由于激光照射引起的疼痛消失可能会使牙髓组织发生一些组织学变化，因此，未来的超微结构研究将发现这些变化。2)临床试验61例，显效10例（16%），有效29例（48%），无效22例（36%）。虽然激光照射产生了立竿见影的效果，但在某些情况下疼痛又回来了。提示对牙本质过敏症的临床资料应进一步研究，以获得更高的临床可靠性。