Analysis of bacterial and host factors in urinary tract infection

我们调查了尿路感染（UTI）的细菌和宿主因素。从尿路感染中分离出的细菌表面有各种各样的菌毛，粘附在尿粘膜上。粘附素（Adhesin）位于肾伞尖端，能刺激多形核白细胞释放大量活性氧，对周围肾组织产生毒性，导致肾瘢痕形成。预防肾脏瘢痕形成是治疗肾脏感染的重要内容之一。我们发现依布硒啉、乌司他丁、类固醇等抗氧化剂对肾脏瘢痕形成有预防作用，这些物质可与抗菌药物联合应用治疗肾脏感染。在临床上，从难治性UTI中分离的表皮葡萄球菌和铜绿假单胞菌中发现了耐药基因，这些耐药基因可转移到其他UTI致病菌中。

We investigated bacterial and host factors in urinary tract infection (UTI). Bacteria isolated from UTI has various kinds of fimbriae on their surface to adhere to urinary mucosa. Adhesin located on the tip of fimbriae is found to stimulate polymorphonuclear leukocytes to release large amount of active oxygen species, which is toxic to surrounding renal tissue, resulting in renal scarring. Prevention of renal scar formation is one of the most important thing in the treatment of renal infection. We found that some kinds of antioxidants such as Ebselen, ulinastatin and steroid had preventive effect on renal scarring, and that these substances were to use combined with antimicrobial agents in the treatment of renal infection. In the clinical field, we found drug resistance genes in Staphylococcus epidermidis and Pseudomonas aeruginosa which were isolated from refractory UTI.These resistance genes were transferable to the other strains of causative bacteria of UTI.