JOINT STUDY ON THE DEVELOPEMENT OF NEW MEDICAL MATERIALS

医用新材料开发联合研究

基本信息

批准号：
06045029
负责人：
MATSUHASHI Akira
金额：
$ 1.86万
依托单位：
TOTTORI UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06045029/
关键词：
Mucopolysaccharide Chitosan Chitin Wound Healing Accelerataion Polymorphonuclear Chemotactic Chemiluminescence Granulation

项目摘要

1. Development of biomedical materials : beta-chitin which was purified from the soft bone of cuttlefish was utilized for implant materials by freeze drying of it's dope or by vacuum filtration of it's dope to the non-woven fabric of polyester (PNWF). alpha-chitin which was purified from the shell of snow crab was deacetylated by a caustic soda and was utilized for the wound covering material by the treatment of mixer on chitosan threads. (Shigemasa, Saimoto, Sashiwa)2. Veterinary application of these materials : Chitin sponge was applied to large tissue defects or skin defect, and chitin-PNWF composite was applied to subcutaneous tissue defect, tendon injury, defect of diaphragm, Many wondering effects were noted in many clinical cases. (Matsuhashi, Minami, Okamoto)3. Investigation of wound healing acceleration mechanism : Many bioactive agents were induced by chitin subcutaneous implantation such as FGF like factor, IL-1, PGE2 and activated compliment. It was clearly demonstrated that chitin and chitosan were a chemotactic factor of PMNs. (Tanaka, Tanigawa, Minami, Okamoto)4. Investigation of wound healing acceleration on experimental created tendon gap : It was clearly demonstrated that chitin accelerated gap healing in the experimental tendon injury model by the histomorphometric and mechanical testing results. (Nelson, Stashak, Norrdin, Okamoto)5. Joint seminar : Three times Joint seminars were held. The first joint seminar was herd in CSU (Sept.12-19, '94), the second one was herd in Tottori (Nov.2-9, '94), and final seminar was herd in CSU (Jul.14-24, '95).6. Publication to the International Congress : The 6th International Congress on Chitin and Chitosan (Gdynia, Poland, 16-19, Aug., '94), World Veterinary Congress '96 (Yokohama, Japan, 3-9, Sept, '95)

1。生物医学材料的开发：通过冷冻干燥其浓汤或真空过滤将其涂料涂成浓料，将其从墨肉的软骨中纯化，用于植入材料。从雪蟹壳中纯化的α-吉他蛋白被苛性苏打脱乙酰基，并通过在壳聚糖螺纹上处理混合器的处理来用于伤口覆盖材料。（Shigemasa，Saimoto，Sashiwa）2。这些材料的兽医应用：将几丁质海绵应用于大组织缺陷或皮肤缺陷，并将几丁质PNWF复合材料应用于皮下组织缺陷，肌腱损伤，隔膜缺陷，在许多临床情况下都注意到许多奇迹作用。（Matsuhashi，Minami，Okamoto）3。对伤口愈合加速机制的研究：许多生物活性剂是由甲壳素皮下植入（例如FGF因素，IL-1，PGE2）和激活的称赞引起的。清楚地表明，几丁质和壳聚糖是PMN的趋化因子。（田中，田川，俄克冈州Minami）4。对实验创建的肌腱间隙的伤口愈合加速度的研究：清楚地表明，通过组织形态计量和机械测试结果，几丁质在实验肌腱损伤模型中加速了间隙愈合。（Nelson，Stashak，Norrdin，Okamoto）5。联合研讨会：举行了三次联合研讨会。第一个联合研讨会是在CSU举行的牛群（94年9月12日至194日），第二个是在托托里（Tottori）（94年11月2日至9日）的牛群，最后的研讨会是在CSU中的牛群（Jul.14-24，'95，'95）.6。国际大会的出版：第六届国际金丁蛋白国际大会（Gdynia，波兰，94年8月16日至19日），世界兽医大会'96（日本横滨，日本，3-9，95年9月，'95）