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A prospective study on the mother-to-infant transmission of hepatitis C virus and the prognosis of the infected infants.

丙型肝炎病毒母婴传播及感染婴儿预后的前瞻性研究。

基本信息

批准号：
06304031
负责人：
SHIRAKI Kazuo
金额：
$ 2.11万
依托单位：
Tottori University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Co-operative Research (A)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06304031/
关键词：
Hepatitis C Mother-to-infants infection Hepatitis C virus HCV RNA Vertical transmission Breast feeding HCV genotype Anti-HCV

项目摘要

Mother-to-infant transmission of hepatitis C virus (HCV) is suspected as one of the most important routes of natural infection of this virus, but its frequency nor factors affecting this infection are not known. Since the carrier status develops even when adults are infected by HCV,which is rare by hepatitis B virus, the retrospective study of the families of HCV carriers cannot elucidate the above mentioned problems. In this research we conducted a prospective follow-up study of the infants born to HCV carrier mothers found by screening or pregnant women.Pregnant women in six different districts of Japan were screened for serum antibody for HCV (second generation, anti-HCV) and if it was positive the serum HCV RNA was examined using polymerase chain reaction. 0.45 to 1.5% (mean 1%) of the pregnant women were positive for anti-HCV,and 71 to 76% of anti-HCV positive women were also positive for serum HCV RNA.Infants born to anti-HCV positive pregnant women were followed after birth with intervals of one to three months for more than one year after birth, examining their sera for anti-HCV,HCV RNA,as well as transaminase levels. Until now 325 infants had been followed for more than six months after birth, and seventeen of them developed chronic HCV carrier status, all of whom were the products of HCV-RNA positive mothers, and none of the infants born to HCV RNA negative mothers showed the sign of HCV infection. The mean percentage of the development of HCV carrier status was 5.4% among the infants born to HCV RNA positive mothers. There were seven other infants who showed transient infection by HCV before six months of age.Close evaluation of various factors regarding mother-to-infant infection disclosed that 1) the mothers of HCV infected infants showed higher serum HCV RNA level, but 2) no difference of infection rate was found between HCV genotypes, 3) between the density gradient status of virus particles in sera, nor 4) between breast-fed and bottle-fed infants.

丙型肝炎病毒（HCV）的母婴传播被怀疑是这种病毒自然感染的最重要途径之一，但其频率和影响这种感染的因素尚不清楚。由于携带者状态即使在成年人感染HCV时也会发展，这在B型肝炎病毒中是罕见的，因此对HCV携带者家庭的回顾性研究不能阐明上述问题。在本研究中，我们对筛查发现的HCV携带者母亲所生的婴儿或孕妇进行了前瞻性随访研究，对日本六个不同地区的孕妇进行了HCV（第二代，抗HCV）血清抗体筛查，如果阳性，则使用聚合酶链反应检测血清HCV RNA。0.45抗-HCV阳性孕妇血清抗-HCV阳性率为1.0%~ 1.5%，平均1.0%，抗-HCV阳性孕妇血清HCVRNA阳性率为71%~ 76%。到目前为止，325名婴儿出生后随访超过6个月，其中17人发展为慢性HCV携带者状态，所有这些人都是HCV-RNA阳性母亲的产物，HCV-RNA阴性母亲所生的婴儿均未显示HCV感染的迹象。HCV RNA阳性母亲所生婴儿中HCV携带者的平均比例为5.4%。另外7例婴儿在6个月前出现一过性HCV感染，对母婴感染的各种因素进行综合分析发现：1）HCV感染婴儿的母亲血清HCVRNA水平较高，但2）HCV基因型之间感染率无差异; 3）血清中病毒颗粒密度梯度状态，也没有4）母乳喂养和奶瓶喂养的婴儿之间。