Basic and clinical research for managemennt of brain tumor

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The treatment of brain tumor is that of cytpreduction through multimodality therapy, including surgery, radiation therapy, chemotherapy and biolgical response modifier.We studied the biological and histological characteristics of brain tumors and tried the new managements of brain tumor using local radiotherapeutic methods. In our chinic, focused radiation to the intracranial lesion is delivered by two different systems, a collimated cobalt-60 source (gammaknife) and a new interstitial radiation source (soft X-rays). The photon radiosurgery system (PRS) device is a lightweight, handheld, battery-powered photon generator. The tip of the probe is 3 mm in diameter and 10cm in length. The energy of X-rays generated decreases sharply with distance from the probe, carrying the potential to effectively irradiate a lesion as large as 3.0cm in diameter at a time. This system can be used without any special radioprotective shielding in an operating theater or a ward [61. We treated 45 patieats with cerebral lesions with a single fraction of interstitial irradiation by PRS after surgery including stereotatic biopsy and partial removal of the tumor. Doserates of 200 cGy per minute are possible, allowing for the administration of 15 Gy to a lesion 3 cm in diameter in less than 20 min. All patients tolerated the procedure weii. No neurological deficits were noted after surgery and irradiation. The clinical efficacy of PRS is now under investigation, but it appears quite promising.