An epidemiologic research to establish the long-term management for Kawasaki disease patients.

一项流行病学研究，旨在建立川崎病患者的长期管理。

• 批准号: 06454245
• 负责人: YANAGAWA Hiroshi
• 金额: $ 4.48万
• 依托单位: Jichi Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06454245/
• 关键词: Kawasaki disease; Epidemiology; Long-term follow-up; Management; Cardiac sequelae; Mortality rates

Objective : To determine whether the mortality rate of patients with a history of Kawasaki disease is higher than that of the general population.Design : In a cohort study, 6576 patients with Kawasaki disease were observed from the first medical encounter because of the disease through the end of 1994, or until death. Standardized mortality ratios (SMR) with 95% confidence intervals (CI) were calculated with vital statistics data of Japan for the control.Results : Of 6576 patients who met the eligibility criteria, 6550 (99.6%) were followed through either the end of the study or the date of death. Twenty patients (14 male subjects) died during the study period ; an overall SMR of 1.35 (95% CI,0.82 to 2.08) was calculated for the entire study period. The SMR was 1.45 (95% CI,0.79 to 2.44) for male subjects and 1.15 (95% CI,0.42 to 2.52) for female subjects. During the acute phase of the disease (the first 2 months after the first visit to hospitals), the SMR was higher, particularly in male subjects (SMR,10.13,95% CI,3.72 to 22.08). After the acute phase, however, both boys and girls had low SMRs. Nine of the 20 deaths were caused by Kawasaki disease ; there were 3 deaths as a result of congenital anomalies of the circulatory system and 2 subjects died of malignant neoplasms of lymphatic or hematopoietic tissues.Conclusions : Although the mortality rate among those with a history of Kawasaki disease was elevated in Japan, many of the deaths that caused the elevation occurred during the acute phase of the disease. The mortality rate was not increased after the acute phase of the disease.

目的：为了确定是否有川崎病史的患者的死亡率高于一般population.Design：在一项队列研究中，6576例川崎病患者进行了观察，从第一次医疗接触，因为到1994年底的疾病，或直到死亡。标准化死亡率比（SMR）与95%的置信区间（CI）与日本的人口统计学数据为control.Results：6576例符合资格标准，6550（99.6%），随后通过研究结束或死亡的日期计算。20例患者（14例男性受试者）在研究期间死亡;整个研究期间计算的总体SMR为1.35（95% CI，0.82 - 2.08）。男性受试者的SMR为1.45（95%CI，0.79 ~ 2.44），女性受试者为1.15（95%CI，0.42 ~ 2.52）。在疾病急性期（首次就诊后的前2个月），SMR较高，尤其是男性受试者（SMR，10.13，95%CI，3.72 ~ 22.08）。然而，在急性期之后，男孩和女孩的SMRs都很低。9的20例死亡是由川崎病造成的，有3例死亡的结果，先天性异常的循环系统和2例受试者死于恶性肿瘤的淋巴或造血tissue.Conclusions：虽然死亡率之间的历史川崎病在日本升高，许多死亡，造成海拔发生在急性期的疾病。在疾病急性期之后，死亡率没有增加。

项目成果

Yanagawa H,et al: "Update of the epidemiology of Kawasaki disease in Japan:from the results of 1993 94 nationwide survev." Journal of Epidemiology. 6・3. 148-157 (1996)

Yanakawa H 等人：“日本川崎病流行病学的最新情况：来自 1993 年 94 次全国调查的结果。”流行病学杂志 6・3（1996 年）。

Nakamura Y,et al.: "Mortality rates for patients with a history of Kawasaki disease in Japan" J Pediatr. 128. 75-81 (1996)

Nakamura Y 等人：“日本有川崎病病史的患者的死亡率”J Pediatr。

Nakamura Y,Yanagawa H,et al.: "Mortality rates for patients with a history of Kawasaki disease in Japan." Journal of Pediatrics. 128・1. 75-81 (1996)

Nakamura Y、Yanakawa H 等：“日本有川崎病病史的患者的死亡率”，《儿科杂志》128・1（1996 年）。

Yanagawa H,et al: "Uodate of the epidemiology of Kawasaki disease in Japan : from the results of 1993 94 nationwide survey." Journal of Epidemiology. 6・3. 148-157 (1996)

柳川 H 等：“日本川崎病的流行病学：来自 1993 年 94 年全国调查的结果。”流行病学杂志 6・3（1996 年）。

Nakamur Y, Yanagawa H, et al.: "Mortality rates for patients with a history of Kawasaki disease in Japan" Journal of Pediatrics. 128. 75-81 (1996)

Nakamur Y、Yanakawa H 等人：“日本有川崎病病史的患者的死亡率”儿科杂志。