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Epidemiologic analyses of risk factors affecting long-term prognosis of Kawasaki disease.

影响川崎病长期预后危险因素的流行病学分析。

基本信息

批准号：
09470116
负责人：
YANAGAWA Hiroshi
金额：
$ 6.21万
依托单位：
Jichi Medical School
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09470116/
关键词：
Kawasaki disease Long-term prognosis Epidemiology Standardized mortality ratios Follow-up 追跡調査

项目摘要

To clarify the long-term prognosis of Kawasaki disease, a multi-center project group followed-up all patients even that stopped visiting medical institutions. The project team consisted of pediatricians of 52 hospitals. All patients who visited the 52 hospitals because of Kawasaki disease from July 1982 through December 1992 were followed-up till the end of 1997, or date of death if it happened before December 1997. First, we checked whether or not to live through resident registration systems. Of 8, 417 patients visiting the hospitals due to Kawasaki disease during the 10 and a half year, 652 suspected cases, 384 recurrent cases, 786 that visited the hospitals on or after 15 days of illness, and 19 foreigners were excluded ; 6, 576 patients were recruited the observation. Of these, 25 had died by the end of observation.The total population-time observed was 65,562 person-years, and the average observation time was 9.7 years. The number of observed deaths during the whole observation period was higher than the expected one for male, in spite of no statistical significance. The standardized mortality ratios were higher during the acute phase, in particular among males. On the other hand, the standardized mortality ratios were closed to 1.0 after the acute phase. However, for patients with cardiac sequelae, in particular male patients, the mortality rate after the acute phase might elevate. Eight patients died during the acute phase, all of whom but one patients dying of injury died of Kawasaki disease ; one was due to encephalopathy caused by Kawasaki disease, and six was due to cardiac lesions caused' by Kawasaki disease. After the acute phase, 17 patients died ; three of ischemic heart disease, 4 of congenital heart disease, 2 of malignant neoplasms in hematologic/immunologic organs, and 8 of other causes.

为了明确川崎病的长期预后，一个多中心项目组对所有患者进行了随访，即使停止了医疗机构的访问。项目组由52家医院的儿科医生组成。对1982年7月至1992年12月因川崎就诊的52家医院的所有患者进行随访，直至1997年底，或1997年12月之前死亡的日期。首先，我们检查了是否通过居民登记制度生活。在10年半期间因川崎病就诊的8417例患者中，疑似病例652例，复发病例384例，发病当天或15天后就诊的786例，排除外国人19例，纳入观察6576例。其中25人在观察结束时死亡，观察的总人口时间为65 562人年，平均观察时间为9.7年。尽管无统计学显著性，但在整个观察期内观察到的雄性动物死亡数量高于预期数量。急性期的标准化死亡率较高，尤其是男性。另一方面，标准化死亡率比在急性期后接近1.0。然而，对于有心脏后遗症的患者，特别是男性患者，急性期后的死亡率可能会升高。8例患者在急性期死亡，除1例死于损伤外，其余均死于川崎病; 1例死于川崎病引起的脑病，6例死于川崎病引起的心脏病变。急性期后，17例患者死亡; 3例缺血性心脏病，4例先天性心脏病，2例血液/免疫器官恶性肿瘤，8例其他原因。