The Basic and Clinical Study for Regional Cerebral Blood Flow in Affective Disorders using stable Xe-CT.

应用稳定氙增强计算机断层扫描（Xe-CT）研究情感性障碍患者的区域脑血流量（rCBF）。研究对象为17例情感性障碍门诊患者，其中11例重度抑郁症（MD）患者和6例双相情感障碍（BD）患者（符合DSM-III-R标准）和10例健康男性志愿者。平均年龄分别为53.2岁、47.0岁和40.4岁。患者和对照组在每个区域的绝对rCBF值都没有出现半球间差异。在MD患者中。与对照组相比，右额叶和双侧中央前皮质区rCBF显著减少。另一方面，BD患者右侧颞叶皮层rCBF明显减少。6例患者（2例MD和4例BD），比较康复前后的rCBF。临床改善的患者皮质血流量无明显变化，但皮质下血流量增加，尤其是基底节区。此外，利用SPECT和^<123>I Iomazenil对情感性障碍和焦虑症患者的中枢苯二氮卓受体结合进行了研究。患者的额、顶叶、颞、枕区结合电位降低。左额叶区和右颞叶区结合电位与HAM-A评分呈负相关

With stable xenon-enhanced computed tomography (Xe-CT), regional cerebral blood flow (rCBF) in the patients with affective disorder were investigated. The subjects were 17 in- and outpatients with affective disorders, which consists of 11 patients with major depression (MD) and 6 patients with bipolar disorder (BD) according to the DSM-III-R criteria, and 10 male healthy volunteers. Their mean ages were 53.2 year, 47.0 year and 40.4 year, respectively. Both patients and controls did not present the interhemispheric differences in absolute rCBF values for every regions. In MD patients. rCBF in right frontal and bilateral precentral cortical regions were significantly reduced as compared with controls. On the other hand, BD patients showed a significant reduced rCBF in right temporal cortex. In six patients (2 MD and 4 BD), the rCBF were compared between before and after recovery. The patients with the clinical improvement showed no remarkable change in cortical blood flow, but they showed increased subcortical blood flow, especially in basal ganglia.In addition, central benzodiazepine receptor bindings using SPECT and ^<123>I Iomazenil in the patients with affective disorders and anxiety disorders were investigated. The binding potential was decreased in frontal, parietal, temporal and occipital region in the patients. The binding potential in left frontal and right temporal area was corelated negatively with HAM-A score