Making peptides orally bioavailable

使肽具有口服生物利用度

• 批准号: DP220103549
• 负责人: A/Prof Richard Clark
• 金额: $ 31.81万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220103549
• 关键词: Making; peptides; orally; bioavailable

Bioactive peptides are exceptionally useful molecules, however to fully realise their exciting applications key limitations need to be overcome: they can't be delivered orally and they do not last long in the body. This project aims to develop a molecular tag that can dramatically enhance both the oral absorption and time in the body of a peptide. This will include identifying the key elements of the tag required for function, the breadth of peptide cargoes it can be applied to and the mechanisms underlying this technology. The outcomes of this project will facilitate the future development of peptides for biotechnology, pharmaceutical and veterinary applications.

生物活性肽是非常有用的分子，但要充分实现其令人兴奋的应用，需要克服关键限制：它们不能口服，并且在体内的持续时间不长。该项目旨在开发一种分子标签，可以显着增强肽的口服吸收和体内停留时间。这将包括确定功能所需标签的关键要素、其可应用的肽货物的广度以及该技术的机制。该项目的成果将促进肽在生物技术、制药和兽医应用领域的未来发展。