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Development of a Spatio-temporal Analyzing System for Cardiac Function by using a Portable RI Monitoring Apparatus

利用便携式 RI 监测仪开发心功能时空分析系统

基本信息

批准号：
06555115
负责人：
AKATSUKA Takao
金额：
$ 5.18万
依托单位：
Yamagata University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research (B)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06555115/
关键词：
Cardiac function Spatio-temporal data processing Portable monitor 3D Time varying image RI monitor Dynamic image recording Long term monitoring Measurement on image Rlモニタ

项目摘要

The final goal of this project is to detect cardiac abnormality in its early stage. For this purpose, cardiac function is spatio-temporarily evaluated by combining data from different modalities. One is the long term observation of cardiac output by newly designed portable monitoring system, and the other is the precise morphological observation of hart taken at intervals. The RI cardiac monitoring system measures continuously RI signals proportional to the volume of RI agents in the left ventricle and the procedures are developed to evaluate cardiac functions from MRI,angiogram and so on.A prototype of the RI monitoring system is composed of a CdTe detector, an amplifier, a spectrum discriminator and a palm size computer. This system detects gamma ray from RI in the patient, and it measeres continuously the specific spectrum peak to discriminate the interesting signal from background scattering. A reference detector is also introduced to compensate background signal. The principle and fundamental characteristics of the system are examined by computer simulation and preliminary experiments with phantom.On the other hand, we have prepared several algorithms for 3D volumetry from MRI and 3D motion analysis from observed image sequence. An integrated display technique is also developed to show cardiac information from different modalities about the same object. Moreover several related imaging and image processing techniques are developed, i.e., SR-CT,ESR-CT and so on.Future problems are to establish more practical monitoring system and to improve integrated evaluation procedures for information from several modalities.

本项目的最终目标是早期发现心脏异常。为此目的，通过组合来自不同模态的数据来时空地评估心脏功能。一是采用新设计的便携式监测系统对心输出量进行长期观察，二是对哈特进行精确的间隔形态学观察。RI心脏监测系统是由CdTe探测器、放大器、频谱分析仪和掌上电脑组成的一个原型系统，它可以连续测量与左心室内RI物质体积成正比的RI信号，并通过MRI、血管造影等手段对心脏功能进行评估。该系统从病人体内的放射性核素中探测γ射线，并连续测量特定的谱峰，以区分感兴趣的信号和背景散射。还引入了参考检测器来补偿背景信号。通过计算机仿真和体模实验，验证了系统的原理和基本特性。另一方面，我们准备了几种用于MRI三维容积测量和观察图像序列三维运动分析的算法。还开发了一种集成显示技术，以显示来自不同模态的关于同一对象的心脏信息。此外，开发了几种相关的成像和图像处理技术，即，今后的问题是建立更实用的监测系统，完善多模式信息的综合评价程序。