The costs and consequences of resistance to stress in microbial systems

微生物系统抵抗应激的成本和后果

• 批准号: DP220103350
• 负责人: Dr Andrew Letten
• 金额: $ 21.62万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220103350
• 关键词: costs; consequences; resistance; stress; microbial

The coexistence of antibiotic resistant and sensitive bacteria in microbial communities represents a paradox. Combining novel ecological models and competition experiments, this project aims to investigate how the pulsing of antibiotics and resources affects the coexistence of resistant and sensitive bacteria. This project expects to generate new knowledge into how the complex non-equilibrium dynamics of natural systems feeds back to regulate the spread of antibiotic resistance in microbial communities. This should advance our fundamental understanding of microbial competition, and provide a foundation for the development of new ecologically-aware strategies for managing resistance.

微生物群落中抗生素耐药细菌和敏感细菌的共存是一个悖论。结合新的生态模型和竞争实验，该项目旨在调查抗生素和资源的脉冲如何影响耐药细菌和敏感细菌的共存。该项目希望产生新的知识，了解自然系统复杂的非平衡动态如何反馈，以调节抗生素耐药性在微生物群落中的传播。这应该会促进我们对微生物竞争的基本理解，并为开发新的具有生态意识的抗药性管理策略提供基础。