Development of a new strategy of hyperthermia for metastatic bone tumor

转移性骨肿瘤热疗新策略的开发

• 批准号: 06557083
• 负责人: TSUBOYAMA Tadao
• 金额: $ 12.67万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06557083/
• 关键词: experimental bone tumor; hyperthermia; intramedullary nail; anti-tumor effects; 転移性骨腫瘍; 実験的転移性骨腫瘍

A new localized hyperthermia system for an experimental bone tumor in the rabbit tibia was developed. This system was composed of an induction coil, generator and a Kirschner wire, which was inserted into the medullary canal of the tibia as a heat-generating ferromagnetic implant. The metastatic bone tumor model was created by implantation of VX2 carcinoma in the medullary canal of the tibia diaphysis. Ten days after VX2 implantation, hyperthermia was induced for 50 min. Three weeks after the treatment, rabbits were sacrificed for histological and radiological evaluation. According to the semi-quantitative scoring system, anti-tumor effects of the single dose of hyperthermia was noted radiologically (<0.01) and histologically (<0.05) where the temperature was at a sufficient level to cause hyperthermia (>42.5ﾟC). This new heating method, which is relatively simple and clinically applicable, appears to be promising for the treatment of metastatic tumors of the long bone. The intramedullary nail of the alloy with low Curie point might make our hyperthermia system much safer and simpler for clinical use than that of stainless steel.

研制了一种新的兔胫骨肿瘤局部热疗系统。该系统由感应线圈、发电机和克氏针组成，作为发热的铁磁性植入物插入胫骨髓管内。在胫骨骨干髓管内种植VX2肿瘤建立骨转移瘤模型。VX2植入后10d，诱导体温升高50min。治疗3周后处死动物，进行组织学和放射学评价。根据半定量评分系统，单次热疗的抗肿瘤效果在放射学(&lt；0.01)和组织学(&lt；0.05)中被注意到，其中温度足以引起热疗(&gt；42.5ﾟC)。这种新的加热方法相对简单，临床适用，是治疗长骨转移瘤的一种有前途的方法。低居里点合金髓内钉可能使我们的热疗系统比不锈钢更安全、更简单。

项目成果

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Takahashi.S.：“高剂量辐照后哈弗系统的长期变化 - 一项超微结构和定量组织形态学研究”J.Bone Joint Surg.76-A。

Takahashi.S.: "The effects of intraoperative radiotherapy on bone healing ability in relation to different doses and post-radiotherapy intervals" Int.J.Radiat.Oncol.Biol.Phys.30. 1147-1152 (1994)

Takahashi.S.：“术中放疗对不同剂量和放疗后间隔对骨愈合能力的影响”Int.J.Radiat.Oncol.Biol.Phys.30。

Ikenaga, M., Ohura, K., Kotoura, Y., Yamamuro, T., Nakamura, T., Oka, M., Hiraoka, M., and Abe, M.: "Hyperthermic treatment of canine tibia through RF inductive heating of an intramedullary nail : a new experimental approach to hyperthermia for metastatic

Ikenaga, M.、Ohura, K.、Kotoura, Y.、Yamamuro, T.、Nakamura, T.、Oka, M.、Hiraoka, M. 和 Abe, M.：“通过射频感应对犬胫骨进行高温治疗

M.Akagi et al.: "Localized hyperthermia for experimental metastatic bone tumor in rabbit tibia using a stainless intramedullary nail." J.Jpn.Orthop.Assoc. 69(8). S1422 (1995)

M.Akagi 等人：“使用不锈钢髓内钉对兔胫骨实验性转移性骨肿瘤进行局部热疗。”

Ikenaga,M.et al.: "Hyperthermic treatment of canine tibia through RF inductive heating of an intramedullary naili a new experimental approach to hyperthermia for metastatic bone fumours." Int.J.Hyperthermia. 10. 507-516 (1994)

Ikenaga,M.等人：“通过射频感应加热髓内钉对犬胫骨进行高温治疗，这是一种治疗转移性骨肿瘤的新实验方法。”