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Portable bioelectrical measurement system for longitudinal developmental study of nervous system functions in infants.

用于婴儿神经系统功能纵向发育研究的便携式生物电测量系统。

基本信息

批准号：
06558006
负责人：
MIYASHITA Mitsumasa
金额：
$ 3.01万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1996
项目状态：
已结题

项目摘要

We developed a portable bioelectrical measurement system which consists of a DAT (Digital Audio Tape) recorder and a small bio-amplifier to study the development of nervous system functions in infants.We first investigated the longitudinal development of reciprocal innervation to examine developmental changes in human motor nervous system. The "radiated" stretch reflex to antagonist muscle in infants and adults, termed "reciprocal excitation", was evaluated. The phasic stretch reflex and the reciprocal excitation were evoked by the Achilles tendon tapping. The surface electromyogram was recorded in the soleus and the tibialis anterior. The reciprocal excitation increased at around the developmental stage of acquisition of standing, and decreased after the acquisition of walking. It was suggested that the spinal neural pathway of reciprocal innervation changed dramatically at these stages of motor development and these changes were related to the acquisition of movements.We next investi … More gated longitudinal changes in the autonomic nervous system activities during the first year of life. Beat-to-beat heart rate variability (HRV ; 600 beats) was recorded from 6 healthy infants (5 males, 1female). HRV data were analyzed by coarse graining spectral analysis to break down their total power (TOT) into harmonic and nonharmonic (fractal) components. The harmonic component was further divided into low (0.0-0.15Hz ; LF)and high (>0.15Hz ; HF)frequency components. The sympathetic (SNS) and parasympathetic (PNS) nervous system activities were evaluated from log (LF/HF) and log (HF/TOT), respectively. The fractal component has the spectrum of 1/f^<beta> and the spectral exponent beta was calculated. There was no consistent pattern of development for SNS and PNS activity indicators among individuals. Spectral exponent beta was, however, negatively correlated (P<0.05)with postnatal age for 4 infants and it tended to decrease rapidly after about 240th day of life. These results indicated that the complexity of HRV increased during postnatal life. Less

我们研制了一套便携式生物电测量系统，该系统由一个DAT（Digital Audio Tape）录音机和一个小型生物放大器组成，用于研究婴儿神经系统功能的发育。评价了婴儿和成人对拮抗肌的“辐射”牵张反射，称为“相互激发”。跟腱轻拍可诱发阶段性牵张反射和相互兴奋。记录比目鱼肌和胫骨前肌的表面肌电图。在获得站立能力的发育阶段前后，交互兴奋增加，获得行走能力后，交互兴奋减少。结果表明，在运动发育的这些阶段，相互支配神经的脊髓神经通路发生了显著的变化，这些变化与运动的获得有关。 ...更多信息在生命的第一年，自主神经系统活动的门控纵向变化。对6例健康婴儿（男5例，女1例）进行心率变异性（HRV ; 600次）测定。心率变异性数据进行了分析，粗粒化频谱分析，将其总功率（TOT）分解为谐波和非谐波（分形）分量。谐波分量进一步分为低频（0.0-0.15Hz ; LF）和高频（>0.15Hz ; HF）分量。分别从log（LF/HF）和log（HF/TOT）评价交感（SNS）和副交感（PNS）神经系统活动。分形分量具有1/f^的谱<beta>，并计算了谱指数β。SNS和PNS活动指标在个体之间没有一致的发展模式。4例婴儿的光谱指数β与出生后年龄呈负相关（P<0.05），在出生后240天左右迅速下降。这些结果表明，HRV的复杂性增加，在出生后的生活。少