Genetic architecture and evolution of complex traits across populations

大多数人类特征都有遗传成分，并在种群内和种群之间显示出相当大的多样性。自然选择如何改变和保持人类特征的遗传变异是进化论中一个长期存在的问题，拟议中的项目旨在回答这个问题。该项目利用创新的统计方法和有史以来最大的不同祖先背景人口的基因组“大数据集”，期望就自然选择在塑造性状遗传变异中的作用产生新的知识，并确定推动人类人口分化的关键因素。这些结果将极大地提高我们对人类特征进化和人口对不断变化的环境的适应的理解。

Most human traits have a genetic component and display substantial diversity within and among populations. How natural selection changes and maintains genetic variation in human traits is a long-standing question in evolution that the proposed project aims to answer. Using innovative statistical methods and largest genomic “big” datasets ever across populations of different ancestral backgrounds, this project expects to generate new knowledge on the roles of natural selection in shaping the genetic variation in traits and identify key factors that drive the differentiation of human populations. These outcomes will significantly improve our understanding on the evolution of human traits and adaptation of populations to changing environments.