Realistic assessment of biomarker transformation in the wastewater system

废水系统中生物标志物转化的现实评估

• 批准号: DP220101790
• 负责人: A/Prof Phong Thai
• 金额: $ 30.23万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-03-15 至 2025-03-14
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220101790
• 关键词: Realistic; assessment; biomarker; transformation; wastewater

Wastewater-based epidemiology is an internationally recognised cost-effective tool to monitor population exposure to chemicals and infectious diseases including Covid-19. However, in-sewer degradation of critical biomarkers can limit their wastewater-based epidemiology suitability. This project aims to systematically evaluate the stability of a new suite of potential biomarkers and conduct the first Australia-wide assessment on the impact of biomarker stability on wastewater-based epidemiology estimates using wastewater samples from ~65% of the Australian population. The project expects to generate knowledge to expand the application of wastewater-based epidemiology to reliably quantify exposure and status of well-being even in remote areas

基于废水的流行病学是国际公认的具有成本效益的工具，用于监测人群接触化学品和包括Covid-19在内的传染病。然而，污水中关键生物标志物的降解限制了其基于废水的流行病学适用性。该项目旨在系统地评估一套新的潜在生物标志物的稳定性，并利用约65%的澳大利亚人口的废水样本，对生物标志物稳定性对基于废水的流行病学估计的影响进行首次澳大利亚范围内的评估。该项目预计将产生知识，以扩大基于废水的流行病学的应用，以可靠地量化即使在偏远地区的接触和健康状况