The new method of brain potentials in children

儿童脑电位新方法

• 批准号: 06670835
• 负责人: OKUDA Osami
• 金额: $ 1.34万
• 依托单位: NIHON UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06670835/
• 关键词: P300; No-Go Potential; audio-motor evoked Potential; mental retardation; development; NO-GO Potentia1; 視覚運動性電位; 聴覚運動性電位; NO-GO Potential

It has been known for a long time that speed and accuracy of performance decline with advancing age. This has been attributed to deficits in attentional mechanisms and to diminished processing resouces. However, most of the ERP studies have been done by simple stimuli task. In this study we used the combined sensational discrimination task. There are combined sensational stimulus that have been done by stimuli experienced in daily life. This task has been done by visuo-motor and audio-motor stimuli and three dimentional figures.We studied P300, No-Go Potentials and audio-motor evoked potentials elicited by combined sensational discrimination task.P300 and No-Go Potentials : The subjects included 91 normals and 25 mentally retarded patients. The age ranged from 3 to 17 years old. The No-Go Potential waveforms became adult form after 3 years of age. The P300 latencies progressively shortened until 13 years old. The No-Go Potential latency-age correlation showed rapid latency till age 9 and shortest at age 13. Of 25 mentally relarded children, 6 (24%) showed prolonged latency beyond 2 S.D..Audio-motor evoked potentials : The waveform consisted to the components of PO,N1, P1, N2 and P2. The latencies of all five potentials were longer in younger children. The latencies progressively shortened until 6 to 7 years old. 30% of mentally retarded children showed prolonged latency as compared to the age matched normal subjects.

人们早就知道，随着年龄的增长，表演的速度和准确性会下降。这被归因于注意力机制的缺陷和加工资源的减少。然而，大多数ERP研究都是通过简单的刺激任务完成的。在这项研究中，我们使用了组合的感觉辨别任务。有组合的感觉刺激，已完成的刺激经验，在日常生活中。本研究采用视觉-运动和听觉-运动刺激及三维图形的方法，对联合感觉辨别任务诱发的P300、No-Go电位和听觉-运动诱发电位进行了研究。年龄3 ~ 17岁。No-Go电位波形在3岁以后变为成人形式。P300潜伏期逐渐缩短，直到13岁。No-Go电位潜伏期与年龄的相关性显示，9岁之前潜伏期较快，13岁时潜伏期最短。在25名智力迟钝儿童中，6名（24%）表现为潜伏期延长超过2S. D。听觉运动诱发电位：波形由PO、N1、P1、N2、P2组成。所有五种电位的潜伏期在年龄较小的儿童中较长。到6 ~ 7岁时，阴茎逐渐变短。30%的弱智儿童潜伏期较同龄正常儿童延长。

项目成果

渕上達夫: "てんかんと電気生理学的検査" 小児内科. 27. 1093-1097 (1995)

Tatsuo Fuchigami：“癫痫和电生理学测试”小儿内科 27. 1093-1097 (1995)。

大久保修: "脳幹聴覚誘発電位の発達による変化" 日大医誌. 55(2). 75-79 (1996)

Osamu Okubo：“脑干听觉诱发电位的发育变化”日本大学医学杂志 55（2）（1996）。

Tatsuo Fuchigami: "Developmental Changes in P300 wave elicid during Two Different Experimenta1 Conditic" PEDIATRIC NEUROLOGY. 13. 25-28 (1995)

Tatsuo Fuchigami：“两种不同实验条件下 P300 波的发育变化”儿科神经病学。

Osami Okubo: "The study of visuo-motor event-related potentials." Recent advances in event-related brain poteatiol research. 763-769 (1996)

Osami Okubo：“视觉运动事件相关电位的研究。”

藤田之彦: "Zonisamideによる発汗障害の検討" 日大医学雑誌. 54. 658-662 (1995)

Yukihiko Fujita：“唑尼沙胺引起的出汗障碍的研究”日本大学医学杂志 54. 658-662 (1995)。