Inhibitory effects of an antiandrogen agent on experimental esophageal carcinoma in rats

抗雄激素药物对大鼠实验性食管癌的抑制作用

• 批准号: 06671312
• 负责人: KONDOH Yasumasa
• 金额: $ 1.34万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06671312/
• 关键词: androgen; Casodex; Esophageal carcinoma; AMN; experimental cancer; casodex

The incidence of esophageal carcinoma (EC) in men are higher than those in women and the androgen receptor has been detected in human skin cytosol. The purpose of this study is to investigate an inhibitory effect of Casodex on EC in castrated rats (CR) and noncastrated rats (NR).The weight of the ventral prostate gland after administration of 'Casodex' mixed into daily solid meal for 10 weeks was measured. The weight of the ventral prostate gland in group of 'Casodex' 25 mg/kg (n=5,132+-30 mg) was significantly lower than that in control group (n=5,713+-133 mg) (p<0.001).The incidence of oesophageal cancer in rats given 'Casodex' for 10 weeks after administration of AMN for 10 weeks was examined histpathologically. The incidence of oesophageal cancer in noncastrated rats administered 'Casodex' as a dose of 25 mg/kg daily (n=7,71.4%) was not lower than that in noncastrated control group (n=9,77.7%). The incidence of oesophageal cancer in castrated rats administered 'Casodex' as a dose of 25 mg/kg daily (n=8,25.0%) was lower than that in castrated control group (n=11,45.4%). We considered that 'Casodex' as a dose of 25 mg/kg has an inhibitory effect on experimental oesophageal cancer in castrated rats.

食管癌男性发病率高于女性，在人皮肤细胞液中检测到雄激素受体。本研究旨在探讨可舒得（Casodex）对去势大鼠（CR）和非去势大鼠（NR）EC的抑制作用。25 mg/kg组（n = 5，132 ± 30 mg）腹侧前列腺重量明显低于对照组（n= 5，713 ± 133 mg）（P<0.001）。非去势大鼠每天给予25 mg/kg的“可舒得”后，食管癌的发生率（n= 71.4%）不低于非去势对照组（n= 9，77.7%）。去势大鼠每天给予25 mg/kg的“可舒得”后，其食管癌发生率（n= 8，25.0%）明显低于去势对照组（n= 11，45.4%）。我们认为，25 mg/kg剂量的“Casodex”对去势大鼠实验性食管癌有抑制作用。

项目成果

近藤泰理: "抗アンドロゲン剤CasodexのAMN(N-Amyl-N-methylnitrosamine)ラット実験食道癌において発癌抑制効果" 日本癌学会総会記事. 第55回. 441- (1996)

Yasuri Kondo：“抗雄激素 Casodex 对大鼠实验性食道癌中 AMN（N-Amyl-N-甲基亚硝胺）的抗癌作用”，日本癌症协会第 55 届大会文章。

近藤泰理: "抗アンドロゲン剤CasodexのAMN(N-Amyl-N-methyl-uitrosamine)ラット実験食道癌における発癌抑制効果" 日本癌学会総会記事. 第55回. 441 (1996)

Yasuri Kondo：“抗雄激素 Casodex 对 AMN（N-Amyl-N-methyl-uitrosamine）实验性食管癌大鼠的致癌作用”，日本癌症协会第 55 届大会文章（1996 年）。

近藤泰理: "非ステロイド性抗アルドロゲン剤CasodexのAMNCN-Auyl-N-wethylvitrosauice" 第45回日本癌学会総会記事. 73 (1995)

Yasushi Kondo：“非甾体抗醛剂 Casodex 的 AMNCN-Auyl-N-wmethylvitrosauice”文章来自日本癌症协会第 45 届年会 73 (1995)。

Yasumasa Kondoh, Akemi Kamijou, Makiko Tanak, Kyoji Ogoshi, Hiroyasu Makuuchi, Tomoo Tajima, Toshio Mitomi: "Inhibitory effects of Casodex, an antiandrogen agent, on experimental esophageal carcinoma induced by AMN (N-Amyl-N-methylnitrosamine) in rats" Ja

Yasumasa Kondoh、Akemi Kamijou、Makiko Tanak、Kyoji Ogoshi、Hiroyasu Makuuchi、Tomoo Tajima、Toshio Mitomi：“抗雄激素药物 Casodex 对 AMN（N-戊基-N-甲基亚硝胺）诱导的大鼠实验性食管癌的抑制作用”