Locoregional cancer chemotherapy of the esophageal cancer

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We deviced three drug delivery systems : bleomycin adsorbed on silica particles (BLM-Sl), bleomycin incorporated into small cylinder of poly d, l-lactic acid (BLM-PLA) and cisplatin incorporated into poly lactic acid / polyethylene glycol acid blend microspheres (CDDP-MS). The results were as followes.1) In a clinical pilot study for esophageal carcinoma, BLm-Sl or blemycin solution (BLM-SOL) was endoscopically injected into the esophageal wall prior to surgery. Bleomycin activity in the lymph nodes and connective tissues was significantly higher in BLM-Sl administration that those in BLM-SOL administration. Degenerative or necrotic changes were microscopically observed in 11 of 36 metastatic lymph nodes. Serious systemic side effects except for fever were not observed.2) In the experimental study on the antitumor effect against Yoshida sarcoma in rats, BLM-PLA was superior to bleomycin solution in both drug distribution and antitumor effect.3) In the experimental model of peritoneal dissemination in rats using Yoshida sarcoma, CDDP-MS was able to control malignant ascites without serious side effect compared with CDDP solution.In conclusion, these three drug formes could be a useful modality for targeting chemotherapy.