The clarification of anti-blood coagulation activity of human placental chorioepithelial brush border membrane

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During pregnancy, blood coagulability and platelet aggreability are enhanced. On the other hand, human placental chorioepithelial brush border membrane which is in direct contact with material blood flow, possesses anti-blood coaglation and anti-platelet aggregatiion activity. We investigated anti-platelet aggregation activity in human placental brush border membrane and its changes in EPH-gestosis. We also investigated anti-coagulation activity in human placental brush border membrane and obtained the following results.A) Human placental brush border membrane posseses potent ADP degrading activity which is closedly related to anti-platelet aggregation activity. We succeeded in partial purification of this ADP degrading enzyme.B) The inhibiting activity of placental brush border membrane against platelet aggregation induced by ADP (adenosine diphosphate) and the ADP degrading activity of placental brush border membrane, decreased prominently compared to control in severe EHP-gestosis. Thus is was indicated that this damaging of anti-platelet aggregation activity in brush border membrane closely related to the pathology of placental dysfunction in EPH-gestosis.C) We clarified the existence of heparin like activity in human placental brush border membrane, and partially characterized this heparin like activity.