成長期における骨形成、吸収の非侵襲的評価法の確立:type I collagenの検討

生长阶段骨形成和吸收的无创评估方法的建立：I型胶原蛋白的研究

• 批准号: 06770559
• 负责人: 久保 俊英
• 金额: $ 0.58万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Encouragement of Young Scientists (A)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06770559/
• 关键词: 小児; 骨代謝; 骨吸収; 骨形成; PICP; ICTP; 成長ホルモン

小児期の骨代謝を解明する目的で,正常小児において,骨形成の指標であるcarboxyterminal propeptide of type I procollagen(PICP)と吸収の指標であるpyridinoline cross-linked telopeptide domain of type I collagen(ICTP)の血中濃度の年齢による変動を測定した.PICP,ICTPとも男女両性において,乳児期と思春期に著明な高値を示す2峰性のピークを示し,いずれの年齢においても成人値に比べて著明な高値を示した.また,その変動は日本人小児の年間身長増加率曲線と平行した動きを示した.従って,小児期には骨形成,吸収の両者が亢進した状態,すなわち高骨代謝回転状態にあると考えられた.更に,成長ホルモン分泌不全性低身長児(GHD)において,成長ホルモン(GH)投与前後でのPICP,ICTPの変動を経時的に測定した.GH投与前の値はいずれも正常コントロールと比べて低値を示した.PICP,ICTPともGH投与にともない投与1ヶ月後には有意に上昇し以後高値を示した.従って,GHDでは骨形成,吸収の両者が抑制された低骨代謝回転状態にあり,GH投与により正常化されると考えられた.また,GH投与1ヶ月後のPICPの上昇率とGH投与1年間の年間身長増加は有意な正の相関を示した.従って,PICPはGH長期投与における身長増加作用を早期に予測する指標になり得ると考えられた.以上より,血中PICP,ICTP濃度の測定は小児期の骨代謝を解明する上でたいへん有用であると考えられる.

The purpose of the baby bone substitute is to understand the purpose of the baby, and the bone formation is called the carboxyterminal propeptide of type I procollagen (PICP). The absorption index is the pyridinoline cross-linked telopeptide domain of type I collagen (ICTP). PICP, PICP, the men and women have the same sex as the baby, and there are two peak signs of sex in the puberty and puberty. Every year, you are more likely to show that you are an adult than you are. The growth curve of the Japanese is parallel to that of the Japanese. In the early childhood, the bone was formed in the small stage, and the smokers became hyperactive, and the high bone substitute returned to the state. What's more, the growth hormone secretes incomplete low body weight (GHD), and the growth cycle (GH) is measured during the previous and subsequent PICP,ICTP exercise. GH investment compared with the previous one. PICP, ICTP GH and post-market performance show that the performance is higher than that of the previous one. Bone formation, GHD bone formation, bone formation and bone formation. GH investment and 1 month later PICP stock rate GH investment and 1-year-old growth intention is closely related to each other. The long-term effect of long-term investment in PICP GH is related to the growth of young people. In the early stage, you can get a lot of money. Above, the blood PICP,ICTP level is determined in the small stage, the bone generation, the bone generation, the bone, the bone and the bone.