New Material Transformation under Unusual Reaction Conditions

异常反应条件下的新材料转化

• 批准号: 07304047
• 负责人: KOTSUKI Hiyoshizo
• 金额: $ 7.55万
• 依托单位: Kochi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07304047/
• 关键词: Organic Synthesis; High Pressure Reaction; Ultrasonic Reaction; Flash Vapor Pyrolysis; Plasma; Radical Reaction; Functional Group Transformation; Unusual Methodology

1 High Pressue Reactions : Synthesis of suprampolecular compounds having a novel molecular recognition property, synthesis of aromatic amines via high-pressure promoted nucleophilic aromatic substitution, transformation of nucleic acids by high-pressure promoted enzyme catalysis, cycloaddition reactions of troponoids, several ogranic functional group transformation such as E-Z isomerization and Michael addition reactions of beta-ketoesters.2 Ultrasonic Reactios : Effect of ultrasonics on the solid state organic reactions, ultrasonic reaction activation of fluorouracil derivatives and their use as prodrags, ultrasonic of organic molecules in aqueous media, ultrasonic activation of oxygen and its mechanistic investigation, ultrasonic fluorination of organic molecules, selective transformation of organic compounds in the solid state.3 Flash Vacuum Pyrolysis : Reactivity of carbenes and nitrenes generated at high pressure in vapor phase, synthesis of novel cyclic organosilicon and organogermanium compounds.4 Plasma Chemistry : Selective transformation of organic materials, generation of radical species, surface treatment of functional polymers, structure and reactivity of peroxyl radicals in the solid state.

1 高压反应：具有新型分子识别特性的超分子化合物的合成、通过高压促进的亲核芳香取代合成芳香胺、通过高压促进的酶催化转化核酸、肌钙蛋白的环加成反应、多种有机官能团的转化，例如E-Z异构化和迈克尔加成反应 β-酮酯。2超声波反应：超声波对固态有机反应的影响，氟尿嘧啶衍生物的超声波反应活化及其作为前药的用途，水介质中有机分子的超声波，氧的超声波活化及其机理研究，有机分子的超声波氟化，固态有机化合物的选择性转化。3 Flash 真空热解：高压气相中产生的卡宾和氮宾的反应性，新型环状有机硅和有机锗化合物的合成。4 等离子体化学：有机材料的选择性转化，自由基物质的产生，功能聚合物的表面处理，固态过氧自由基的结构和反应性。

项目成果

M.Kuzuya: "Effect of Alkyl Substitution on Plasma-Induced Free Radicals of Cellulose Derivatives" Proceedings of Japanese Symposium on Plasma Chemistry. 9. 55-60 (1996)

M.Kuzuya：“烷基取代对纤维素衍生物等离子诱导自由基的影响”日本等离子体化学研讨会论文集。

5) H.KOTSUKI,M.Teraguchi, N.Shimomoto, and M.Ochi: "Ytterbium (III) Trifluoromethanesulfonate Catalyzed High Pressure Reaction of Epoxides with Indole. An Enantioselective Synthesis of (+)-Diolmycin A2" Tetrahedron Lett.37. 3727-3730 (1996)

5) H.KOTSUKI、M.Teraguchi、N.Shimomoto 和 M.Ochi：“三氟甲磺酸镱 (III) 催化环氧化物与吲哚的高压反应。( )-Diolmycin A2 的对映选择性合成”四面体 Lett.37。

6) H.KOTSUKI: "Epoxide Ring Opening Reaction at High Pressure" KAGAKUKOGYO. 47. 845-849 (1996)

6) H.KOTSUKI：“高压环氧化物开环反应”KAGAKUKOGYO。

5) S.V.Chapyshev and T.IBATA: "New Type of Quinone-quinone Complexation in the Reaction of 2,5-Dichloro-1,4-benzoquinone with Morpholine at High Pressure" Russ.Chem.Bull.45. 469-470 (1996)

5) S.V.Chapyshev 和 T.IBATA：“高压下 2,5-二氯-1,4-苯醌与吗啉反应中的新型醌-醌络合”Russ.Chem.Bull.45。

5) H.TOMIOKA,and K.Taketsuji: "Flash Vacuum pyrolysis of Trifluoromethylated Diphenyldiazomethanes. Role of Trifluoromethyl Group on the Arylcarbene Rearrangement" J.Chem.Soc.Chem.Commun.1745-1746 (1997)

5) H.TOMIOKA, and K.Taketsuji:“三氟甲基化二苯基重氮甲烷的快速真空热解。三氟甲基对芳基碳烯重排的作用”J.Chem.Soc.Chem.Commun.1745-1746 (1997)