Experimental analysis of behavior of Fyn-deficient mice
Fyn缺陷小鼠行为的实验分析
基本信息
- 批准号:07451018
- 负责人:
- 金额:$ 4.1万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:1995
- 资助国家:日本
- 起止时间:1995 至 1996
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Fyn protein is one of the non-receptor type tyrosine kinases of the Src family and is strongly expressed in the brain. Mice deficient for the fyn gene were examined for their susceptibility to acoustically primed audiogenic seizures and seizures induced by various convulsive drugs, including mertrazol, picrotoxin, bicuculline, kainic acid, NMDA and strychnine. Homozygous mutant (fynz/fynz) mice were significantly more susceptible to audiogenic seizures. They were also more likely to show myoclonic convulsions than were heterozygous mutants (+/fynz) when metrazol, picrotoxin, bicuculline, kanic acid and NMDA were administered. On the other hand, no difference in seizure susceptibility was found between homozygous and heterozygous mutants when strychnine was administered. These results suggest a role of Fyn in seizures induced by loud acoustic stimulus and by convulsive drugs (anti-GABAeregic and glutamic/aspatic acid excitatory receptor agonists).
Fyn蛋白是Src家族的非受体型酪氨酸激酶之一,在大脑中强烈表达。观察fyn基因缺失小鼠对声源性听性癫痫的易感性,以及各种惊厥药物(包括mertrazol、picrotoxin、bicuculline、kainic acid、NMDA和士的宁)引起的癫痫的易感性。纯合子突变(fynz/fynz)小鼠更容易发生听原性癫痫发作。与杂合突变体(+/fynz)相比,给药时,他们更容易出现肌阵挛性惊厥,如美曲唑、微毒素、双曲霉素、kanic酸和NMDA。另一方面,纯合子突变体和杂合子突变体在服用士的宁时癫痫易感性没有差异。这些结果表明Fyn在由高声刺激和惊厥药物(抗gabaegic和谷氨酸/阿斯丁酸兴奋受体激动剂)引起的癫痫发作中起作用。
项目成果
期刊论文数量(17)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Yasunaga,M.,Yagi,T.,Hanzawa,N.et al: "Involvement of Fyn tyrosine kinase in progression of cytokinesis of Blymphocyte progennitor." J.Cell Biol.132. 91-99 (1996)
Yasunaga,M.,Yagi,T.,Hanzawa,N.等人:“Fyn 酪氨酸激酶参与 B 淋巴细胞祖细胞胞质分裂的进展。”
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- 影响因子:0
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Kai, N., Mishina, M & Yagi, T.: "Molecular cloning of Fyn-associated molecules in the mouse central nervous system" J.Nearosci Res. (In Press).
凯,N.,三品,M
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- 影响因子:0
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Miyakawa,Yagi,Taniguchi,Matsuura,Tateishi & Niki: "Enhanced susceptibility of audiogenic seizures in Fyn-deficient mice." Molecular Brain Research. 28. 349-352 (1996)
宫川、八木、谷口、松浦、立石
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- 影响因子:0
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Miiyakawa, M,Yagi, T,Kagiyama, A & Niki, H: "Radial maze performance open-field and elevated plus-maze behaviors in Fyn-deficient mice." Molecular Brain Research. 37. 145-150 (1996)
宫川 M、八木 T、梶山 A
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- 影响因子:0
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Miyakawa,T,Yagi,T,Tateishi,K & Niki,H: "Susceptibility to drug-induced seizures of Fyn tyrosine kinase-deficient mice" Neuro Report. 7. 2723-2726 (1996)
宫川,T,八木,T,立石,K
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NIKI Hiroaki其他文献
NIKI Hiroaki的其他文献
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{{ truncateString('NIKI Hiroaki', 18)}}的其他基金
Ethanol Sensitivity of Fyn-deficient mice
Fyn 缺陷小鼠的乙醇敏感性
- 批准号:
09410023 - 财政年份:1997
- 资助金额:
$ 4.1万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Functional Roles of the Top-Down Information Processing in Cognitive Processes
自上而下的信息处理在认知过程中的功能作用
- 批准号:
05301011 - 财政年份:1993
- 资助金额:
$ 4.1万 - 项目类别:
Grant-in-Aid for Co-operative Research (A)
Physiological basis of recognition
识别的生理基础
- 批准号:
61450013 - 财政年份:1986
- 资助金额:
$ 4.1万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
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12670007 - 财政年份:2000
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Ethanol Sensitivity of Fyn-deficient mice
Fyn 缺陷小鼠的乙醇敏感性
- 批准号:
09410023 - 财政年份:1997
- 资助金额:
$ 4.1万 - 项目类别:
Grant-in-Aid for Scientific Research (B)