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Study and gene ralization of "Oscillator and gate operators model" in vasomotor center

血管运动中枢“振荡器和门控模型”的研究与推广

基本信息

批准号：
07457012
负责人：
NINOMIYA Ishiro
金额：
$ 2.75万
依托单位：
HIROSHIMA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

项目摘要

To examine our "oscillater and gate operator model" aortic pressure, aotic nerve activity, cardiac sympathetic nerve activity (CSNA) and ECG were measured Simultaneously during rest and exercise in conscious freely-moving cuts and separately in anesthetized rats (BW : 0.2-0.4kg), cats (2-4kg) and swines (20-50kg). Periodicity, peak neight and width of synchronized CSNA and renal sympathetic nerve activity (RNA) were analyzed by the cluster program and the delay time of synchronized CSNA and RNA from the R wave of ECG was measured The interval histograms show two modes consisting 8-12Hz (Tc) and cardiacrelated (Tb) rlythms. The modes of Tc rlythm were almost the same in all of the rats, cats and swines whereas the modes of Tb rlythm changed depending on the cardiac intervals. The Tc rlythm (8-12Hz) did not influeced by baroceptor input, heart rate and chemoreeptor inputs. The results indicate that the Tc rlyth is the common fundameutal rlythm of central origin and is independent of the size of neural network and body weight. The probability of synchrouized RNA was maximum at delouy time of 50ms and 180ms in the rats and swines, respectirely, and then deveused rapidly near Zero due to pulsatile beroceptor input. These results suggest that the gate operators oppened at the maxim probability while it closed at the minimum probubility.

为了检测我们的“振荡和门操作员模型”主动脉压，我们在麻醉大鼠（体重0.2-0.4kg）、猫（2-4kg）和猪（20-50kg）的清醒自由运动切口休息和运动时同时测量了听神经活动、心脏交感神经活动（CSNA）和心电图。采用聚类程序分析同步CSNA和肾交感神经活动（RNA）的周期性、峰夜和宽度，并测量同步CSNA和RNA在心电图R波中的延迟时间。大鼠、猫和猪的Tc节律模式几乎相同，而Tb节律模式则随心脏间隔时间的变化而变化。节律（8-12Hz）不受气压感受器、心率和化学感受器输入的影响。结果表明，该节律是中枢起源的共同基本节律，与神经网络的大小和体重无关。在大鼠和猪体内，同步RNA的概率分别在50ms和180ms时达到最大，随后由于脉动性受体的输入，同步RNA的概率迅速接近于零。这些结果表明，栅极算子以最大概率打开，而以最小概率关闭。