ONTOGENESIS AND ABERRATION OF HEART RATE VARIATION CONTROL IN RELATION TO INFLUENCING PHENOMENON IN THE HUMAN FETUS

心率变异控制的个体发生和畸变对人类胎儿的影响现象

• 批准号: 07457390
• 负责人: KOYANAGI Takashi
• 金额: $ 4.86万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07457390/
• 关键词: Ontogenesis; Ultradian rhythm; Fetal heart rate variation; Active and quiet phases; Fetal stomach movement; Werner syndrome; Preeclampsia; Neutrophil degranulation; 先天性十二指腸閉鎖症; 超音波電子スキャン; 最小二乗メディアン法; active; quiet phase; 胃の蠕動運動; ウルトラディアンリズム

We summarized our study entitled the ontogenesis and aberration of heart rate (FHR) variation control in relation to influencing phenomenon in the human fetus.1.With regrd to the extent to which a given heart rate correlates with the following heart rate(s) at any gestational age, a linear decrement in "beat-delay" from 21 beats (mean) at 23-25 weeks to 11 beats at 28-29 weeks' gestation was noted, suggesting that the conduction system-oriented heart beat gradually comes under functional control of the autonomic nervous system as well as under possible regulation by the maturing medulla oblongata. From this point in gestation thereafter, there were no significant changes in "beat-delay", thereby implying that FHR variation becomes stabilized as a result of the control rendered by the more developed autonomic nervous system function.2.As for the rhythmic changes in fetal stomach movement (FSM), two different conditions stratified with statistical significance were present. Chronological … More ly, these changes appeared to cluster into the "active" and "quiet" phases at 29 weeks' gestation onwards. The underlying mechanism of this rhythmicity is likely to demonstrate the development of ultradian rhythm pertaining to the FSM,under control of the central nervous system function.3.A case of Werner syndrome characterized by premature aging was evident to have the potential risk of reproductive problems such as incompetent cervix, premature labor, intrauterine growth retardation and hypertensive disorder.4.The neutrophil degranulation observed in preeclampsia revealed a decrease in the total granule content retained in neutrophil. This suggests that in preeclampsia, a possible modification mechanism exists, specific in neutrophil degranulation and different from the N-formyl-methionyl-leucyl-phenylalanine-induced superoxide production system.Whether or not the maternal conditions described in the later two categories possibly contribute to FHR variation remain to be further elucidated. Less

我们总结了我们的研究，题为心率变异的个体发生和异常控制与人类胚胎中的影响现象有关。1.随着给定心率与随后的心率(S)在任何胎龄的相关性的程度的恢复，注意到“搏动延迟”从23-25周的21次(平均)线性减少到28-29周的11次，这表明面向传导系统的心率逐渐受到自主神经系统的功能控制，并可能受到成熟的延髓的调节。从妊娠后的这一点，“心跳延迟”没有明显的变化，从而意味着FHR的变异变得稳定，这是由于更发达的自主神经系统功能的控制。2.至于胎儿胃运动(FSM)的节律性变化，存在两种不同的情况，具有统计学意义。按年代排序的…更确切地说，这些变化似乎在妊娠29周后进入“活跃”和“平静”阶段。这种节律性的潜在机制可能表明，在中枢神经系统功能的控制下，与FSM有关的超传统节律的发展。3.以过早衰老为特征的Werner综合征明显存在生殖问题的潜在风险，如宫颈功能不全、早产、宫内发育迟缓和高血压疾病。4.先兆子痫患者观察到的中性粒细胞脱颗粒显示中性粒细胞中保留的总颗粒含量减少。这表明在子痫前期中，可能存在一种不同于N-formyl-methionyl-leucyl-phenylalanine-induced超氧化物产生系统的中性粒细胞脱颗粒的修饰机制。后两类中描述的母体情况是否可能导致胎心率的变化仍有待进一步阐明。较少

项目成果

M.Ogawa: "Pregnancy complicated with Werner syndrome." Obstetrics & Gynecology. 88. 722. (1996)

M.Okawa：“怀孕并发维尔纳综合征。”

H.Nakano: "Fetal heart rate variation describes a long-term developmental course of the human fetus, normal and abnormal." In C.Yabes-Almirante and M.B.de Luna eds.Increasingly Safe and Successful Pregnancies. Amsterdam : Elsevier. 199-206 (1996)

H.Nakano：“胎心率变化描述了人类胎儿的长期发育过程，正常和异常。”

H.Nakano: "In C.Yabes-Almirante and M.B.de Luna eds.Increasingly Safe and Successful Pregnancies.Amsterdam:Elsevier." Fetal heart rate variation describes a long-term developmental course of the human fetus,normal and abnormal., 199-206. (1996)

H.Nakano：“C.Yabes-Almirante 和 M.B.de Luna 编辑的《越来越安全和成功的怀孕》。阿姆斯特丹：Elsevier。”

Ogawa M: "Pregnancy complicated by Werner syndrome." Obstetrics and Gynecology. 722 (1996)

小川 M：“怀孕并发维尔纳综合征。”

H.Amagase: "Neutrophil Degranulation Activity in Preeclampsia." HYPERTENSION IN PREGNANCY. 16・2. 203-212 (1997)

H.Amagase：“先兆子痫中的中性粒细胞脱粒活性。”16・2（1997）。