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Ontogenetic development of neural control of the heart rate in the human fetus quantitatively assessed using a probability matrix.

使用概率矩阵定量评估人类胎儿心率神经控制的个体发育。

基本信息

批准号：
01570935
负责人：
KOYANAGI Takashi
金额：
$ 1.41万
依托单位：
Kyushu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1989
资助国家：
日本
起止时间：
1989 至 1991
项目状态：
已结题

项目摘要

For the past 3 years, we quantitatively analyzed, using a probability matrix, the age-related fetal heart rate changes in the fetuses with hydrocephalus and anencephalous as well as the normal fetuses.1. Analyzed was the age-related characteristics of FHR variation in normal fetuses from 20 to 41 weeks' gestation, using the "congruence rate" between the standard matrix constructed from the original whole data in each 2 consecutive gestational age and the matrix produced from a small sample of FIIR data randomly selected from the original data set, as a parameter. The minimum number of FHR beats necessary to get a "congruence rate" of 90% for the standard probability matrix was 2700 beats at 27-28 weeks' gestation, gradually increasing up to about 6000 beats at 34-35 weeks' gestation. Two statistically significant critical points were found to be at 28-29 weeks' and at 34-35 weeks' gestation. These findings indicate that there were 3 different characteristics of FHR variation pertaining … More to the mechanism. of PIIR control throughout the gestational periods studied.2. Refering to the standard probability matrix for the corresponding gestational week, the age-related differences in fetal heart rate change in anencephalic or hydrocephalic fetuses was evaluated, using the 'incongruence rate" as a parameter, representing the difference between the standard matrix and the subjected matrix. In hydrocephalic fetuses, the -incongruence rate- remained within the normal range, between 11.8 and 30.6% at 31-39 weeks' gestation. On the contrary, in anencephalic fetuses, the "incongruence rate" increased, with advance in gestation, from 15.9-40.6% at 24 weeks' gestation to 36.5-45.3% at 34 weeks' gestation. and the values were beyond the normal range from 31 weeks' gestation onwards. Combining these results with autopsy findings, these suggest that the central nervous system, cephalate to the medulla, begins to play a substantial role in the control of fetal heart rate changes, at least, from 31 weeks' gestation onwards. Less

近3年来，我们应用概率矩阵定量分析了脑积水、无脑儿及正常胎儿胎心率随年龄的变化.以连续2个胎龄的全部原始数据构成的标准矩阵与从原始数据集中随机抽取的小样本FIIR数据构成的矩阵的“一致率”为参数，分析了20 ~ 41周正常胎儿FHR变化的年龄相关特征。对于标准概率矩阵，获得90%的“一致率”所需的FHR搏动的最小数量在妊娠27-28周为2700次搏动，逐渐增加到妊娠34-35周约6000次搏动。发现两个具有统计学意义的临界点在妊娠28-29周和34-35周。这些结果表明，有3个不同的特点，胎心率变异有关， ...更多信息到机制。PIIR控制整个妊娠期研究。参照相应孕周的标准概率矩阵，以“不一致率”为参数，代表标准矩阵与受试矩阵之间的差异，评价无脑或脑积水胎儿胎心率变化的年龄相关差异。在脑积水胎儿中，不一致率在妊娠31-39周时保持在正常范围内，在11.8%和30.6%之间。相反，无脑畸形胎儿的“不一致率”随孕龄的增加而增加，从孕24周的15.9-40.6%增加到孕34周的36.5-45.3%。从孕31周开始，这些值超出正常范围。结合这些结果和尸检发现，这些结果表明，中枢神经系统，头端到髓质，开始发挥实质性的作用，在控制胎儿心率的变化，至少从31周的妊娠开始。少