Renal protective effect of sinorphan, an enkephalinase inhibitor

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Nephrotoxixity is the most bothersome adverse effect of cyclosporine A (CyA), an immunosuppressive agent, and can result in irreversible renal damage. The agent is widely used for the treatment of patients with organ transplant. Therefore, it is important that the drug-induced nephrotoxicity be prevented.In these studies, the effects of sinorphan, an enkephalinase inhibitor, on CyA-induced adverse events including nephrotoxicity and its immunosuppressive action were examined.The following results were obtained ;1)Sinorphan protects against the CyA-induced renal damage.2)Sinorphan prevents the elevation of blood pressure, probably by inhibition of enhanced endothelin production by CyA.3)Sinorphan does not influence the imunosuppressive action fo CyA.4)Sinorphan does not alter the CyA concentration in blood.These results that sinorphan prevents the CyA-induced adverse events without changing the pharmacologic effecfts of CyA.