Preventive effect of an enkephalinase inhibitor on drug-induced nephrotoxicity.

脑啡肽酶抑制剂对药物引起的肾毒性的预防作用。

• 批准号: 05671902
• 负责人: FUJIMURA Akio
• 金额: $ 1.34万
• 依托单位: Jichi Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05671902/
• 关键词: ANP; sinorphan; cyclosporin; amikacin; nephrotoxicity

Nephrotoxicity is one of adverse effects observed during treatment with cyclosporin, a potent immunosuppressive agent, and amikacin, an aminoglycoside antibiotics. The present study was undertaken to examine whether sinorphan, an enkephalinase inhibitor, might prevent a cyclosporin-or amikacin-induced nephrotoxicity. Male Wistar rats received cyclosporin (50mg/kg・day, orally) or amikacin (250mg/kg・day, intraperitoneally) with or without sinorphan (50mg/kg・day, orally) for 14 days.The reduction in creatinine clearance and the elevations in urinary NAG excretion and plasma renin activity were observed in rats treated with cyclosporin or amikacin alone. Morphological changes in renal tissue were demostrated in these animals. However, the degree of the drug-induced renal damage was lessened in rats treated with both the nephrotoxic agent and sinorphan. These results suggest that sinorphan might prevent the nephrotoxicity caused by cyclosporin and amikacin.

肾毒性是在使用强力免疫抑制剂环孢素和氨基糖苷类抗生素阿米卡星治疗期间观察到的不良反应之一。本研究旨在研究脑啡肽酶抑制剂辛诺芬是否可以预防环孢素A或阿米卡星所致的肾毒性。雄性Wistar大鼠口服环孢素(50 mg/kg·d)或阿米卡星(250 mg/kg·d)加或不加辛诺芬(50 mg/kg·d)，连续14d，观察环孢素或阿米卡星对大鼠尿NAG排泄量和血浆肾素活性的影响。观察了这些动物肾脏组织的形态变化。然而，在同时使用肾毒性药物和辛诺芬的大鼠中，药物所致的肾损害程度有所减轻。提示辛诺芬对环孢素和阿米卡星所致的肾毒性有保护作用。

项目成果

Akio Fujimura: "Preventive effect of sinorphan,an enkephalinase inhibitor,on cyclosporin-induced nephrotoxicity." Canadian Journal of Physiology and Pharmacology. 72. 584- (1994)

Akio Fujimura：“脑啡肽酶抑制剂 Sinorphan 对环孢菌素引起的肾毒性的预防作用。”

Akio Fujumura, Ken-ichiro Sunaga, Akio Ebihara :"Preventive effect of sinorphan, an enkephalinase inhibitor, on cyclosporin-induced nephrotoxicity." Canadian Journal of Physiology and Pharmacology.72. 584 (1994)

Akio Fujumura、Ken-ichiro Sunaga、Akio Ebihara：“脑啡肽酶抑制剂 Sinorphan 对环孢菌素诱导的肾毒性的预防作用。”

Akio Fujimura: "Preventive effect of sinorphan,an enkephalinase inhibitor,on cyclosporin-induced nephrotoxicity." Canadian Journal of Physiology and Pharmacology. 72. 584 (1994)

Akio Fujimura：“脑啡肽酶抑制剂 Sinorphan 对环孢菌素引起的肾毒性的预防作用。”