ODC gene overexpression and carcinogenesis of intestinal epithelial cells
ODC gene overexpression and carcinogenesis of intestinal epithelial cells
批准号:
07457594
负责人:
BAMBA Tadao
金额:
$0.19万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
1995
资助国家:
日本
项目状态:
已结题
起止时间:
1995 至 1996
中文摘要
大多数结肠癌组织中ODC活性和腐胺含量较高。我们选择了ODC活性高的癌组织,提取RNA,用RT-PCR方法扩增ODC cDNA,测序结果表明,所有ODC cDNA均未发生突变。我们推测结肠癌组织中ODC活性的升高与ODC蛋白的稳定性有关。我们将研究抗酶突变与ODC活性的关系。
英文摘要
Most of colon cancer tissue poses high ODC activity and putrescine content. We chose some of cancer tissues with extensively high ODC activity, extracted RNA and mede ODC cDNA by RT-PCR.Unfortunately, all of ODC cDNA which were sequenced did not has mutation. We speculate that much higher ODC activity of colon cancer was associated with the stability of ODC protein. We will investigate the relation antizyme mutation and ODC activity.
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会议论文
the role of short-chain Fatty acids in the intestine
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批准号:12470121
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.02万
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财政年份:2000
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负责人:BAMBA Tadao
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依托单位:
Clinical application of evaluation of complement protein levels in the exocrine pancreas to determine the pancreatic disease activity
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批准号:09470135
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.61万
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财政年份:1997
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负责人:BAMBA Tadao
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依托单位:
海外基金