The comparison between HLA-DRB1 genotypes and the clinical features of rehumatoid arthritis and the other rheumatic diseases.

HLA-DRB1基因型与类风湿性关节炎及其他风湿性疾病临床特征的比较

• 批准号: 07457606
• 负责人: OGAWA Ryokei
• 金额: $ 2.05万
• 依托单位: Kansai Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07457606/
• 关键词: Rheumatoid arthritis; Osteoarthritis; Genetic marker; HLA; Cytokine; Type II collagen; Obesity; 骨破壊

The relationship between HLA-DRB1 genotypes and the clinical features of rheumatoid arthritis (RA) and other rheumatic diseases was assessed.1.In the relationship between HLA-DRB1 genotypes and progression of bone destruction with RA (n=329), the bone destruction of the patients with homozygosity for rheumatoid susceptible alleles (HLA-DRB1**0405 and 0101) of HLA-DRB1 was more rapid significantly than that of the patients with heterozygosity or none for the susceptible alleles.2.The difference of the gene frequencies of HLA-DRB1 between osteoarthritis (OA,n=52) and RA (n=329) patients was assessed. The frequency of HLA-DRB1**0405 was significantly higher in our patients with RA than in OA subjects. The frequency of HLA-DRB1**0101 in OA and RA patients was significantly higher than in the healthy Japanese subjects (n=493).3.The relationship between serum levels of interleukin-6 (IL-6) and the presence of the susceptible allele HLA-DRB1 of RA (n=56). In the early phase group, the serum l … More evel of IL-6 was significantly correlated with the presence of HLA-DRB1**0405. In latephase of groups, however, there was no correlations between the serum level of IL-6 and the presence of HLA-DRB1**0405. HLA-DRB1**0405 may play an important role in controlling the expression of IL-6 in the early phase of RA,and thus be related to disease severity in Japanese RA patients.4.The correlation between the efficacy of type II collagen (CII) treament of the RA (n=38) and the presence of HLA-DRB1**0405 allele was investigated in two groups of patients : the first group had HLA-DRB1**0405 allele (0405 group) and the second had no such allele (the non-0405 group). The differences in the number of swollen and tender joints were statistically significant between the 0405/CII and 0405/placebo groups, and between the 0405/CII and non-0405/CII groups.5.We assessed the symptoms of knee OA induced by obesity and the effect of weight loss on the obese patients with knee OA.In the obese group, 18 patients were received a program of weight loss with a low calorie diet for 6 weeks (the diet group) and 10 patients were not done (the non-diet group). The effect of a diet therapy in this study on weight loss was a 4.6(]SY.+-。[)1.0 kg. In the diet group at final assessment, the symptoms of pain during noctural bedrest, increased pain with remaining standing for 30 min and the ability of going up stairs were significantly improved compared with baseline, although the symptoms did not significantly recovered in the non-diet group. The symptoms of knee OA is correlated with not only genetic factors but also acquired factors. Less

1.在人类白细胞抗原-DRB1基因分型与类风湿关节炎(RA，n=329)骨破坏进展的关系中，类风湿易感等位基因(HLADRB1**0405和0101)纯合子患者的骨破坏速度明显快于易感基因杂合子或无杂合子的患者。在我们的RA患者中，HLA-DRB1**0405的频率显著高于OA患者。RA患者和OA患者的HLADRB1**0101频率明显高于日本健康人群(n=493)。3.血清IL-6水平与RA易感等位基因HLADRB1存在的关系(n=56)。早期组：血清L…IL-6水平的升高与HLADRB1**0405的存在显著相关。然而，在晚期组中，血清IL-6水平与存在HLA-DRB1**0405之间没有相关性。在日本类风湿关节炎患者的早期阶段，HLA-DRB1**0405可能在控制IL-6的表达方面起着重要作用，并与疾病严重程度相关。4.研究了类风湿关节炎患者(n=38)使用II型胶原(CII)治疗的疗效与人类白细胞抗原-DRB1**0405等位基因存在的相关性：第一组患者存在HLA-DRB1**0405等位基因(0405组)，第二组患者(非-0405组)没有该等位基因。0405/CII组和0405/安慰剂组、0405/CII组和非0405/CII组之间关节肿胀和压痛的差异有统计学意义。5.我们评估了肥胖引起的膝骨性关节炎的症状和减肥对肥胖膝关节骨性关节炎患者的影响。在肥胖组中，18例患者接受了为期6周的低热量饮食减肥计划(节食组)，10例患者不进行减肥(非饮食组)。在这项研究中，饮食疗法对减肥的影响为4.6(SY.+-)。[)1.0公斤。饮食组夜间卧床疼痛症状、站立30min后疼痛加重、上楼能力较基线明显改善，而非饮食组症状未见明显恢复。膝关节骨性关节炎的症状不仅与遗传因素有关，还与后天因素有关。较少

项目成果

竹村 清介、戸田 佳孝、小川 亮惠 他: "慢性関節リウマチ患者と変形性膝関節症患者におけるHLA-DRB1対立遺伝子頻度の比較" 臨床リウマチ. 9巻. 131-135 (1997)

Seisuke Takemura、Yoshitaka Toda、Ryoe Okawa 等：“类风湿性关节炎患者和膝骨关节炎患者的 HLA-DRB1 等位基因频率比较”，《临床风湿病学》第 9 卷，131-135 (1997)。

Yoshitaka Toda, Seisuke Takemura, Tadanobu Morimoto, Ryokei Ogawa: "The relationship between obesity and symptoms in patients with osteoarthritis of the knee. (In Japanese)" Orthopedic Surgery. Vol.49 (In Press). (1998)

Yoshitaka Toda、Seisuke Takemura、Tadanobu Morimoto、Ryokei Okawa：“膝骨关节炎患者肥胖与症状之间的关系。（日语）”骨科手术。

Yoshitaka Toda, Seisuke Takemura, Ryokei Ogawa et al.: "Relationship between duration of rheumatoid arthritis prior to knee joint surgery and HLA-DRB1 alleles : A retrospective study." J Rheumatol. Vol.24. 2304-2307 (1997)

Yoshitaka Toda、Seisuke Takemura、Ryokei Okawa 等人：“膝关节手术前类风湿关节炎持续时间与 HLA-DRB1 等位基因之间的关系：一项回顾性研究。”

Yoshitaka Toda, Seisuke Takemura, Tadanobu Morimoto, Ryokei Ogawa: "Relationship between HLA-DRB1 genotypes and efficacy of oral type II collagen treatment using chicken cartilage soup in rheumatoid arthritis. (In Japanese)" J Clin Immun. Vol.20. 52-59 (1

Yoshitaka Toda、Seisuke Takemura、Tadanobu Morimoto、Ryokei Okawa：“HLA-DRB1 基因型与使用鸡软骨汤口服 II 型胶原蛋白治疗类风湿关节炎疗效之间的关系。（日语）” J Clin Immun。

戸田佳孝 他: "慢性関節リウマチ患者のHLA-DRB1対立遺伝子の組み合わせと骨破壊進行度との関連性について" リウマチ. 35. 514-520 (1995)

Yoshitaka Toda 等：“HLA-DRB1 等位基因的组合与类风湿性关节炎患者骨质破坏程度的关系”Rheumatology 35. 514-520 (1995)。