The comparison between HLA-DRB1 genotypes and the clinical features of rehumatoid arthritis and the other rheumatic diseases.

评估HLA-DRB1基因型与类风湿关节炎（RA）及其他风湿性疾病临床特征的关系。在HLA-DRB1基因型与RA骨破坏进展的关系中（n=329），类风湿易感等位基因（HLA-DRB1**0405和0101）纯合子的患者骨破坏速度明显快于易感等位基因杂合子或无合子的患者。评估骨关节炎（OA,n=52）和RA （n=329）患者HLA-DRB1基因频率的差异。HLA-DRB1**0405在RA患者中的频率明显高于OA患者。OA和RA患者HLA-DRB1**0101的频率显著高于日本健康人（n=493）。血清白细胞介素-6 （IL-6）水平与RA易感等位基因HLA-DRB1存在的关系（n=56）。在早期组，血清IL-6水平与HLA-DRB1**0405的存在显著相关。而在各组晚期，血清IL-6水平与HLA-DRB1**0405的存在无相关性。HLA-DRB1**0405可能在RA早期控制IL-6的表达中发挥重要作用，从而与日本RA患者的病情严重程度有关。研究II型胶原蛋白（CII）治疗RA （n=38）的疗效与HLA-DRB1**0405等位基因存在的相关性。两组患者：第一组患者存在HLA-DRB1**0405等位基因（0405组），第二组患者不存在HLA-DRB1**0405等位基因（非0405组）。0405/CII组与0405/安慰剂组、0405/CII组与非0405/CII组之间肿胀和压痛关节数量的差异均有统计学意义。我们评估了肥胖引起的膝关节炎的症状以及减肥对肥胖膝关节炎患者的影响。在肥胖组中，18名患者接受了为期6周的低热量饮食减肥计划（节食组），10名患者没有接受减肥计划（非节食组）。在这项研究中，饮食疗法对体重减轻的影响为4.6(]SY.+- . [)1.0 kg。在最终评估时，饮食组夜间卧床时的疼痛症状、站立30分钟后的疼痛增加以及上楼能力与基线相比有显著改善，尽管非饮食组的症状没有明显恢复。膝关节骨性关节炎的症状不仅与遗传因素有关，还与后天因素有关。少

The relationship between HLA-DRB1 genotypes and the clinical features of rheumatoid arthritis (RA) and other rheumatic diseases was assessed.1.In the relationship between HLA-DRB1 genotypes and progression of bone destruction with RA (n=329), the bone destruction of the patients with homozygosity for rheumatoid susceptible alleles (HLA-DRB1**0405 and 0101) of HLA-DRB1 was more rapid significantly than that of the patients with heterozygosity or none for the susceptible alleles.2.The difference of the gene frequencies of HLA-DRB1 between osteoarthritis (OA,n=52) and RA (n=329) patients was assessed. The frequency of HLA-DRB1**0405 was significantly higher in our patients with RA than in OA subjects. The frequency of HLA-DRB1**0101 in OA and RA patients was significantly higher than in the healthy Japanese subjects (n=493).3.The relationship between serum levels of interleukin-6 (IL-6) and the presence of the susceptible allele HLA-DRB1 of RA (n=56). In the early phase group, the serum l … More evel of IL-6 was significantly correlated with the presence of HLA-DRB1**0405. In latephase of groups, however, there was no correlations between the serum level of IL-6 and the presence of HLA-DRB1**0405. HLA-DRB1**0405 may play an important role in controlling the expression of IL-6 in the early phase of RA,and thus be related to disease severity in Japanese RA patients.4.The correlation between the efficacy of type II collagen (CII) treament of the RA (n=38) and the presence of HLA-DRB1**0405 allele was investigated in two groups of patients : the first group had HLA-DRB1**0405 allele (0405 group) and the second had no such allele (the non-0405 group). The differences in the number of swollen and tender joints were statistically significant between the 0405/CII and 0405/placebo groups, and between the 0405/CII and non-0405/CII groups.5.We assessed the symptoms of knee OA induced by obesity and the effect of weight loss on the obese patients with knee OA.In the obese group, 18 patients were received a program of weight loss with a low calorie diet for 6 weeks (the diet group) and 10 patients were not done (the non-diet group). The effect of a diet therapy in this study on weight loss was a 4.6(]SY.+-。[)1.0 kg. In the diet group at final assessment, the symptoms of pain during noctural bedrest, increased pain with remaining standing for 30 min and the ability of going up stairs were significantly improved compared with baseline, although the symptoms did not significantly recovered in the non-diet group. The symptoms of knee OA is correlated with not only genetic factors but also acquired factors. Less