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BASIC RESEARCH ON BIOLOGICAL EFFECTS OF MAGNETIC FIELDS

磁场生物效应的基础研究

基本信息

批准号：
07458235
负责人：
UENO Shoogo
金额：
$ 3.9万
依托单位：
University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1997
项目状态：
已结题

项目摘要

This project focuses on the effects of intense static magnetic fields on the behavior of diamagnetic water and paramagnetic oxygen.1.Parting of Water by Magnetic Fields ( Moses Effect). When studying the properties of diamagnetic fluids in static magnetic fields up to 8T we observed the phenomena that the surface of the water was pushed back by magnetic fields of higher gradients.2.Redistribution of Dissolved Oxygen Concentration. The spatial distribution of oxygen concentration dissolved in water was measured by a dissolved oxygen meter. A clear redistribution of oxygen concentration was observed, and the dissolved oxygen concentration increased more then 10% around the center of the magnet.3.Effect of Magnetic Fields on Peripheral Blood Circulation and Skin Temperature In Vivo. We studied the effect of 8T static magnetic fields on the peripheral blood flow, blood pressure, heart rate, and body temperature of an anesthetized rat. Blood flow decreased by 10% during magnetic field exposure. Skin temperature decreases may be attributable to the accelerated evaporation of water from the skin by magnetic fields.Biochemical Reactions Catalyzed by Catalase, Xanthine Oxidase, and Other Enzymes Under Intense Magnetic Fields. We studied whether magnetic fields of up to 14T affect the activity of several enzymes. We observed no effect on the reaction of superoxide-dismutase, peroxidase, and xanthine oxidase. However, we observed changes in the absorbance of the reaction mixture of hydrogen peroxide and catalase during and after magnetic field exposures. The results indicate that magnetic fields affect the dynamic movement of oxygen bubbles that are produced in the reaction mixture by the decomposition of hydrogen peroxide, but not the catalytic activity of the catalase itself.

本计画主要研究强静磁场对抗磁性水及顺磁性氧行为的影响。1.磁场对水的分离（摩西效应）。在研究抗磁性流体在8T静磁场中的性质时，我们观察到了水的表面被更高梯度的磁场推回的现象。2.溶解氧浓度的重新分布。用溶解氧仪测定了水中溶解氧浓度的空间分布。在磁场作用下，氧浓度发生了明显的再分布，在磁场中心附近，溶解氧浓度增加了10%以上。3.磁场对外周血循环和皮肤温度的影响。我们研究了8T静磁场对麻醉大鼠外周血流量、血压、心率和体温的影响。在磁场暴露期间，血流量下降了10%。皮肤温度的降低可能是由于磁场加速了皮肤水分的蒸发。强磁场下过氧化氢酶、黄嘌呤氧化酶等酶催化的生化反应。我们研究了高达14 T的磁场是否会影响几种酶的活性。我们没有观察到超氧化物歧化酶，过氧化物酶和黄嘌呤氧化酶的反应的影响。然而，我们观察到的过氧化氢和过氧化氢酶的反应混合物的吸光度的变化过程中和磁场暴露后。结果表明，磁场影响过氧化氢分解反应混合物中产生的氧气气泡的动态运动，但不影响过氧化氢酶本身的催化活性。