EVALUATION OF WEIGHT CHARTING AND HUMORAL FACTORS AFFECTING EATING AND SATIETORY CENTERS IN OBESE SUBJECTS

大多数关于肥胖受试者体重减轻的研究都未能保持数年的体重减轻，所谓反弹现象的机制尚不完全清楚。报道了每日体重模式图表作为辅助减肥的效果。我们在1995年至1997年间接受我们减肥计划的135名女性中评估了它的疗效。减肥计划开始时的平均年龄和BMI分别为48.2（±±）和0.7（平均±±）。(SE)和29.2 (SY。+ -。)分别为0.2 (kg / m2)。所有肥胖受试者被要求在2年内绘制每日体重图表。3-羟基丁酸（3HB）和瘦素这两种体液因子从脂肪组织释放到血液中，影响大脑的进食和饱腹中枢。研究人员在进行包括营养、运动和行为治疗在内的3.5个月的减肥计划前后进行了测量。在减肥计划中，34%的肥胖受试者的体重减轻了5%以上（A组），但其余肥胖受试者的体重没有减轻（B组）。我们以0分（无图）到100分（完全）的评分来评估权重图的完成程度，并比较a组（71.2(]SY.+- .[)2.5）和B组（42.9(]SY.+- .[)2.7）的评分平均值。A组与B组比较，差异有统计学意义（P<0.001）。体重指数与瘦素水平的相关性一直很高（P<0.001），无论是在减肥过程中，还是在反弹现象中，都存在瘦素抵抗。但是，3HB与BMI之间没有这种相关性，而3HB在减肥方案后增加了1.5 M。上述结果表明，绘制每日体重模式有助于减肥，血瘦素水平反映脂肪组织的数量。

Most of the studies on weight reduction in obese subjects failed to maintain thier weight loss for several years and mechanisms of the so-called rebound phenomenon are not fully understood. The efeicacy of charting of daily weight pattern as an aid towaed weight reduction was reported. We evaluated its efficacy in 135 pbese femaled who were admitted to our weight reduction program between 1995 and 1997. Average age and BMI at the beginning of weight reduction program were 48.2(]SY.+-。[)0.7 (mean(]SY.+-。[)SE), and 29.2(]SY.+-。[)0.2 (kg/m2) respectively. All obese subjects are requested to chart their daily weight for 2 years. Two humoral factors, 3-hydroxybutyric acid (3HB) and leptin, released from adipose tissues into the blood affecting a feeding and a satietory center in the brain, were measured before and after weight reduction program which includes nutrition, expercise and behavioral treatment for 3.5monthes. During the weight reduction progra, 34% lost their more than 5% of their initial weight (group A), but the remaining obese subjects failed to loose weight (group B). We evaluated the degree of completion in weight charting as a score from 0 (no charting) to 100 (perfect) and the mean of the score was compared between group A (71.2(]SY.+-。[)2.5) and B (42.9(]SY.+-。[)2.7). The difference between group A and B was statistically significant (P<0.001). The correlation between BMI and leptin level was consistently high (P<0.001) in not only during weight reduction but also rebound phenomenon, sugesting leptin resistance. But, such correlation was not found between 3HB and BMI,while 3HB increased 1.5 M After weight reduction program. These results suggest that charting of daily weight pattern is effective aid for weight reduction and blood leptin level refrects the amount of fat tissuies.