Preparation of chemically bonded anatite for biomaterials

生物材料用化学键锐钛矿的制备

• 批准号: 07555275
• 负责人: UMEGAKI Takao
• 金额: $ 5.38万
• 依托单位: TOKYO METROPOLITAN UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07555275/
• 关键词: biomaterials; apatite; hydraulic hardening; chemically bouded ceramics; water-soluble polymer; MDFセメント

Preparation of hydraulic hardened bodies of calcium phosphates was carried out adding polyacrylamide, polymethylmetacrylate, monomer of acrylamide. Hydrolysis of calcium phosphates were remarkably retarded by the above additives at room temparature and accelerated 80ﾟC.Thermal decomposition products of hydroxyapatite, alpha-Ca_3 (PO_4)_2, beta-Ca_3 (PO_4)_2 and amorphous calcium phosphate were used as calcium phosphate cements.Acrylamide monomer in the thermal decomposition products of apatite was polimerized at first and then the calcium phosphate cements were heated in water. The calcium phosphate hardened bodies thus obtained were found to be about 1.7 in bulkdensity and 11-12 MP a in bending strength, which was doubled compared with that obtained on no addition of polymers. In addition to the above hydration conditions, bridging agents for acrylamide monomer was used on the preparation of hydraulic calcium phosphates. The calcium phosphate bodies containing the bridging agent were found to be about 1.8 in bulk density and about 20 MPa in bending strength. Silica addition into calcium phosphate cements improved the workability of the cement slurries.

添加聚丙烯酰胺、聚甲基丙烯酸甲酯、丙烯酰胺单体制备磷酸钙水硬硬化体。上述添加剂在室温下显着延缓磷酸钙的水解，在80℃则加速磷酸钙的水解。以羟基磷灰石、α-Ca_3(PO_4)_2、β-Ca_3(PO_4)_2和无定形磷酸钙的热分解产物作为磷酸钙骨水泥。热分解产物中的丙烯酰胺单体 首先将磷灰石聚合，然后将磷酸钙骨水泥在水中加热。发现由此获得的磷酸钙硬化体的堆积密度为约1.7，弯曲强度为11-12MPa，与未添加聚合物时获得的相比增加了一倍。除上述水合条件外，在制备水硬磷酸钙时还使用了丙烯酰胺单体的架桥剂。发现含有架桥剂的磷酸钙体的堆积密度为约1.8，弯曲强度为约20MPa。在磷酸钙水泥中添加二氧化硅可改善水泥浆的和易性。

项目成果

T.Umegaki,K.Yamashita: "Anatite Ceramics and related Phosphates" Phosphorus Res.Bull.Vol.6. 22-25 (1996)

T.Umegaki、K.Yamashita：“锐钛矿陶瓷和相关磷酸盐”Phosphorus Res.Bull.Vol.6。

K.Muroyama,K.Yamashita,T.Umegaki: "Preparation of Hydranlic Hardened Body of Caleium Phosphotes Containing polymer" Phosphorus Res.Bull.Vol.6. 310-313 (1996)

K.Muroyama、K.Yamashita、T.Umegaki：“含磷酸钙聚合物的液压硬化体的制备” Phosphorus Res.Bull.Vol.6。

Y.Kawahara,T.Umegaki K.Yamashita: "Effect of Silica Addition on Mechanical Strength of Hydraulic Hardened Caleium Phosphate" Phosphorus Res.Bull.Vol.6. 206-209 (1996)

Y.Kawahara、T.Umegaki K.Yamashita：“添加二氧化硅对水硬磷酸钙机械强度的影响”Phosphorus Res.Bull.Vol.6。

室山健治、松本利美、山下仁大、梅垣高士: "リン酸カルシウム類の水和硬化体調製時における水溶性高分子添加の効果" 無機マテリアル. 3巻. 380-385 (1996)

Kenji Muroyama、Toshimi Matsumoto、Hitoshi Yamashita 和 Takashi Umegaki：“在水合硬化磷酸钙制备过程中添加水溶性聚合物的效果”，无机材料，第 3 卷，380-385 (1996)。

松本,山下,梅垣: "高分子添加にリン酸カルシウム質セメント硬化体の合成" 第33回セラミック基礎討論会. (1995)

Matsumoto、Yamashita、Umegaki：“添加聚合物的硬化磷酸钙水泥的合成”第 33 届陶瓷基础研讨会（1995 年）。