Research on Nano-Characterization for Apatite Growth Surface

磷灰石生长表面的纳米表征研究

• 批准号: 12450271
• 负责人: UMEGAKI Takao
• 金额: $ 8.64万
• 依托单位: Tokyo Metropolitan University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12450271/
• 关键词: Atomic Force Microscopy; Surface Potential Microscopy; Apatite Crystal Growth; Bioglass; In Situ Observation; Simulated Body Fluid; 表面電位電位顕微鏡; 生体活性ガラス

Artificial hydroxyapatite and Bioglass【○!R】 are well known as bioactive materials in a medical field. During an implantation of these materials in a human body, the materials are gradually bonded to a natural bone thorough a bonelike calcium phosphate apatite layer formed by chemical reactions of the bioactive materials in human body fluid around 37℃. However, the chemical reactions occurring on the material surfaces have not been understood, well. In order to obtain some new information on this problem, a direct observation technique has been used. In this study, an in situ atomic force microscope combined with surface potential measurement was used to observe the apatite formation on the Bioglass【○!R】 in simulated body fluid (SBF). From the observation, it can be seen that small islands with 5-10 nm size are formed on the Bioglass【○!R】 surface in the initial period (within 1 hour). These islands correspond to nuclei of apatite. These nuclei grew very slowly in SBF solution. This means that the growth of nuclei is a limiting process for the formation of the calcium phosphate apatite layer.

人工羟基磷灰石和生物玻璃[○！R]是医学领域中众所周知的生物活性材料。在将这些材料植入人体期间，这些材料通过生物活性材料在约37℃的人体体液中的化学反应形成的类骨磷酸钙磷灰石层逐渐结合到天然骨上。然而，在材料表面发生的化学反应还没有被很好地理解。为了获得关于这个问题的一些新的信息，使用了直接观察技术。在这项研究中，使用原子力显微镜结合表面电位测量来观察生物玻璃[○！R]在模拟体液（SBF）中。从观察中可以看出，在生物玻璃[○！R]表面在初始阶段（1小时内）。这些岛对应于磷灰石的核。这些晶核在SBF溶液中生长非常缓慢。这意味着晶核的生长是磷酸钙磷灰石层形成的限制过程。