DEVELOPMENT OF APLICATION AND PREPARATION OF FANCTION CONTROLLED BIODEGRADABLE MICROCUPSULES

扇控生物可降解微囊的应用开发及制备

• 批准号: 07556112
• 负责人: KAWANO Yoshinobu
• 金额: $ 0.38万
• 依托单位: MIYAZAKI UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07556112/
• 关键词: MICROCUPSULES; BIODEGRADATONABLE; (W; O; W) EMULSION; FUNCTIONABLE; EXTRACTION; IN SITU PORIMERIZATION; DRING IN LIQUID PHASE; in-situ重合; スチレンポリマー; バイオポール; ポリ乳酸; 中空

PREPARATION OF MICROCUPSULES AND BEADS,AND RELEASE CHARACTER OF FUNCTIONAL REAGENTS CONTAINING IN THE MICROCUPSULES WERE INVESTIGATED FOR VARIOUS CONDITIONS.PREPARATION METHODS FOR MICROCUPSULES AND BEADS HAVING MACRO AND MICRO PORES WERE ESTABLISHED USING IN SITU PORIMARIZATION AND SOLVENT VAPORIZATION IN (O/W) OR (W/O/W) COMPLEX EMULSION.IN THIS INVESTIGATION,THE FOLLOWING RESULTS WERE OBTAINED (1) STYRENE/DIVINYLBENZENE COPORIMER MICROCUPSULES AND BEADS WERE ESTAB LISHED TO PREPARE.MICROPORE SIZES IN BEADS WAS SHOWN TO CONTROLLED BY SOLVENT USED IN THE ORGANIC PHASE OF (O/W) EMULSION.SIZES OF SUBMICRON ORDER PORES CONSTRUTED IN THE BEADS WERE AFFECTED BY RELATIVE RATE OF THE INNER AQUEOUS PHASE AND SOLVENT VAPORIZATION.(2) PREPARATION METHODS OF BIODEGRADATIONABLE POLYMER BEADS AND MICROCUPSULES USING SOLVENT VAPORATION METHOD WERE ESTABLISHED USING (W/O/W) EMULSION.THE SHAPE OR CONSTRUCTION OF MACROPORES IN THE BEADS WERE SHOWN TO CONTROLLED BY THE CONCENTRATIONS OF MATERIALS IN INNER AND OUTER AQUEOUS PHASES AND SOLIDIFOCATION RATES OF SHELL MATERIALS.

研究了不同条件下微囊和微球的制备及微囊中功能性试剂的释放特性。建立了微囊和微球在(O/W)或(W/O/W)复合乳剂中的原位聚合和溶剂挥发制备方法。结果表明：(1)用(W/O/W)法制备了苯乙烯/二乙烯基苯共聚微球和微球，微球中的微孔大小受(O/W)乳液有机相中所用溶剂的控制，微球中亚微米有序孔的大小受内水相相对速率和溶剂挥发速率的影响。(2)建立了(W/O/W)溶剂蒸发法制备聚合物微球和微球的方法。

项目成果

YOSHINOBU KAWANO: ""CHARACTERISTIC OF RELEASE AND STABILITIES FOR PROTEIN IN (W/O/W) EMULSION"" 24TH FORAM FOR USE OF FANCTIONAL METERIALS. 38-41 (1995)

YOSHINOBU KAWANO：“（W/O/W）乳液中蛋白质的释放和稳定性特性”第 24 届功能材料使用论坛。

SHIRO KIYOYAMA: ""PREPARATION OF BIODEGRADATIONABLE MICROCUPSULES BY SOLVENT EVAPORATION USING (W/O/W) COMPLEX EMULSION"" PRINTED IN KAGAKUKOGAKU RONBUNSYU. (1997)

SHIRO KIYOYAMA：“使用（W/O/W）复合乳液通过溶剂蒸发制备可生物降解微囊”，印刷于 Kagakukogaku Ronbunsyu 上。

KAZUYA IJICHI: ""PREPARATION OF MICROCUPSULES BY IN SITU COPORYMERIZATION IN (W/O/W) EMALUSION"" PRINTED IN KAGAKUKOGAKU RONBUNSYU. (1997)

Kazuya Ijiichi：“通过原位共聚合在（W/O/W）电子化中制备微囊””印刷于 Kagakukogaku Ronbunshuu。

吉澤秀和: "Preparation of Divinylbenzene Homopolymeric Microcapsules with Highly Porpus Memprane by in situ Polymerization with Solvent Evaporation" J.Chem.Eng.,Japan. 28. 78-84 (1995)

Hidekazu Yoshizawa：“通过原位聚合和溶剂蒸发制备具有高度多孔膜的二乙烯基苯均聚物微胶囊”J.Chem.Eng.，日本 28. 78-84 (1995)。

吉澤 秀和: "多核型マイクロカプセル調製に与える複合乳化条件の検討" 第26回機能材料と利用に関するフォーラム. 39-42 (1996)

Hidekazu Yoshizawa：“制备多核微胶囊的复杂乳化条件的研究”第26届功能材料与利用论坛39-42（1996）。