DEVELOPMENT OF APLICATION AND PREPARATION OF FANCTION CONTROLLED BIODEGRADABLE MICROCUPSULES

考察了微杯和微球的制备及微杯中功能试剂的释放特性，建立了在（O/W）或（W/O/W）复合乳液中原位聚合和溶剂挥发法制备具有大、微孔的微杯和微球的方法。（1）制备了苯乙烯/二乙烯基苯共聚物微杯和微球，微球的孔径大小受（O/W）有机相溶剂的控制。乳液.珠粒中的亚微米级孔的大小受内部水相和溶剂蒸发的相对速率的影响。(2)本文建立了以（W/O/W）乳液为原料，溶剂蒸发法制备生物降解聚合物微球和微杯的方法，微球中大孔的形状和结构受内外水相中物质浓度和壳材料固化速率的控制。

PREPARATION OF MICROCUPSULES AND BEADS,AND RELEASE CHARACTER OF FUNCTIONAL REAGENTS CONTAINING IN THE MICROCUPSULES WERE INVESTIGATED FOR VARIOUS CONDITIONS.PREPARATION METHODS FOR MICROCUPSULES AND BEADS HAVING MACRO AND MICRO PORES WERE ESTABLISHED USING IN SITU PORIMARIZATION AND SOLVENT VAPORIZATION IN (O/W) OR (W/O/W) COMPLEX EMULSION.IN THIS INVESTIGATION,THE FOLLOWING RESULTS WERE OBTAINED (1) STYRENE/DIVINYLBENZENE COPORIMER MICROCUPSULES AND BEADS WERE ESTAB LISHED TO PREPARE.MICROPORE SIZES IN BEADS WAS SHOWN TO CONTROLLED BY SOLVENT USED IN THE ORGANIC PHASE OF (O/W) EMULSION.SIZES OF SUBMICRON ORDER PORES CONSTRUTED IN THE BEADS WERE AFFECTED BY RELATIVE RATE OF THE INNER AQUEOUS PHASE AND SOLVENT VAPORIZATION.(2) PREPARATION METHODS OF BIODEGRADATIONABLE POLYMER BEADS AND MICROCUPSULES USING SOLVENT VAPORATION METHOD WERE ESTABLISHED USING (W/O/W) EMULSION.THE SHAPE OR CONSTRUCTION OF MACROPORES IN THE BEADS WERE SHOWN TO CONTROLLED BY THE CONCENTRATIONS OF MATERIALS IN INNER AND OUTER AQUEOUS PHASES AND SOLIDIFOCATION RATES OF SHELL MATERIALS.