Application of polyphenol in plants for antibody of lipids degaradation and aging

植物多酚在抗脂质降解和衰老抗体中的应用

• 批准号: 14550740
• 负责人: KAWANO Yoshinobu
• 金额: $ 2.24万
• 依托单位: Miyazaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14550740/
• 关键词: Astachisantine; β-carotin; Tocopherole; Oxygen absorption rate; Squarene; Linoleic acid; Microcapsuration; Green tea catecine; 紫外線照射; βーカロテン; 抗酸化剤; 過酸化物; マイクロカプセル化; 連鎖反応; 生分解性ポリマー; リン酸3カルシュム

The reactor for measurement of lipids oxidation in the initial step was developed. Very small degree of oxidation could be measured continuously in the reactor. On the other hand, oxydation of lipid irradiated ultraviolet was measured by the flow type reactor. Oxidation mechanism was established using both experimental results. The oxidation proceeded through the induction and acceleration periods. The oxidation in induction was controlled by suppresion of radicals and oxygen absorption reagents.Antibody on the lipid of astachisanchin, β-carotene and green tea catechine were investigated. These reagents acts on supplement of oxidation of induction period. However, β-caroten and astachisanchine did not act the suppresion of oxidation in the acceleration period. Green tea catechine suppresed strongly the oxidation of lipid in both steps, induction and acceleration periods. The suppresion factor was greater than that of α-tocopherol. To avoid of excces antioxidants, microcapulation technique for antioxidants were investigated for various conditions. Optimum operation technique was proposed by the release controll of anitioxidants. The oxidation of lipids was accelerated by irradiation of ultraviolet in both steps. The oxidation rate equation was established as follows :dCp/dt=9.31x10^<28>exp(-2.7510^4/T)xI(-8.59x10^<-3>T^<3.13>)xCs^<2.0>where value of I is a intense of ultraviolets

研制了油脂氧化反应器。可以在反应器中连续测量非常小的氧化程度。另一方面，用流动式反应器测定了紫外线照射下脂质的氧化反应。氧化机理建立使用这两个实验结果。氧化过程经历了诱导期和加速期。通过抑制自由基和吸氧剂控制诱导过程中的氧化，研究了不同浓度的抗体对虾青素、β-胡萝卜素和绿色茶儿茶素脂质的影响。这些试剂对诱导期的氧化起补充作用。而β-胡萝卜素和虾青素对加速期的氧化没有抑制作用。绿色茶儿茶素在诱导期和加速期均能显著抑制脂质的氧化。抑制因子大于α-生育酚。为了避免过量的抗氧化剂，研究了不同条件下的抗氧化剂微胶囊化技术。通过控制抗氧剂的释放，提出了最佳操作工艺。紫外线照射加速了脂质的氧化。建立了氧化速率方程：dCp/dt= 9.31 × 10 ~（^4）<28>exp（-2.7510 ~（^4）/T）× I（-8.59 × 10 ~<-3>（<3.13>^4）T ~（^4）× Cs ~（^4）<2.0>其中I值为紫外线强度

项目成果

塩含浸活性炭を芯物質とすた生分解性マイクロカプセルの調製

以盐浸渍活性炭为芯材的可生物降解微胶囊的制备

• 发表时间: 2004
• 期刊: 化学工学論文集 30
• 作者: 塩盛弘一郎;谷口仁;小玉誠;清山史朗;河野恵宣;幡手泰雄
• 通讯作者: 幡手泰雄

Development of Semi-batch Preparation System for Microcapsules

微胶囊半间歇制备系统的研制

• 发表时间: 2002
• 期刊: J.Chemical Industry and Engineering (China) 53
• 作者: Y.KAWANO;K.SHIOMORI;S.KIYOYAMA;Y.HATATE
• 通讯作者: Y.HATATE

K.Kiyoyama, Y.Kawano, K.Shiomori, Y.Hatate: "The Recovery of Organic Acid and by Degradatable Microcapsules Entrapped Both Extractant and Adsorbent"Proc. 2002 Kyusyu/Korea/Taipei Chem. Eng. Conf.,. (CD-ROM). (2002)

K.Kiyoyama、Y.Kawano、K.Shiomori、Y.Hatate：“有机酸的回收以及通过捕获萃取剂和吸附剂的可降解微胶囊”Proc。

H.Hatate, K.Yamamoto, Y.Kawano, Y.Hatate: "Reduction of Antioxidant Activity of Using Fish Liver Microsome s-Development A New Experiment Animal Substituted for Rat"Poc. 2002 Kyusyu/Korea/Taipei Chem. Eng. Conf.,. (CD-ROM). (2002)

H.Hatate、K.Yamamoto、Y.Kawano、Y.Hatate：“使用鱼肝微粒体降低抗氧化活性-开发替代大鼠的新实验动物”Poc。

S.KIYOYAMA, K.SHIOMORI, Y.KAWANO, Y.HATATE: "Entrapment Efficiencies of Inorganic Salt into Cross-lonked or Biodegradable Microcapsules"J. Chemical Industry and Engineering (China)). 53. 273-274 (2002)

S.KIYOYAMA、K.SHIOMORI、Y.KAWANO、Y.HATATE：“无机盐在交联或可生物降解微胶囊中的捕获效率”J。