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Development of Education and Research Support System for Human Embryology using Three-Dimensional Fetus Image Reconstruction

基于三维胎儿图像重建的人类胚胎学教育和科研支持系统的开发

基本信息

批准号：
07557182
负责人：
KOMORI Masaru
金额：
$ 1.86万
依托单位：
KYOTO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

项目摘要

This research is aimed for development of a system that acquires digital data of fetus specimen, reconstructs 3D image from them and visualizes in various way.In the first step (1995), image acquisition system from a microscope was developed. The XY-stage of a microscope was modified to be able to rotate, so that a specimen image was aligned rapidly under overlaid display of continuous slices. Comparing with a photograph which was prepared before the fetus had been sliced, those acquired image set were adjusted more precisely.In the second step (1996), the visualization system of 3D image was developed. Not only simple surface image of body and organs but also overlaid 3D image organs with transparent body surface can be displayed. Virtual section image in arbitrary direction of reconstructed 3D image can be viewed. Some of those image were picked up and put on a WWW server (The URL is http : //www.kuhp.kyoto-u.ac.jp/VE/). Selected image and movie were recorded into VCR tape and used in a lecture of anatomy for medical students. The whole slice image were acquired for nine normal human fetus specimen in Carnegie Stage 13 to 23, 3D image of body, inner ear, neural tube and heart are reconstructed.A trial of synthesis of growing process using several actual image data is in a prototype stage yet. Analysis of the difficulties is still undergoing. This system is based on NIH Image software with several modifications.

本研究的目的是开发一套胎儿标本的数字化数据采集系统，从胎儿标本中重建三维图像，并以多种方式可视化。显微镜的XY工作台被改装成可以旋转，这样在连续切片的叠加显示下，样品图像可以快速对准。与胎儿切片前准备的照片相比，采集的图像集调整得更精确。第二阶段(1996)，开发了3D图像可视化系统。不仅可以显示简单的身体和器官的表面图像，还可以显示具有透明身体表面的覆盖的3D图像器官。可以查看重建3D图像的任意方向上的虚拟截面图像。其中一些图像被提取并放到WWW服务器上(URL是http：//www.kuhp.kyoto-U.S.ac.jp/ve/)。选定的图像和电影被录制到VCR磁带上，并用于医学生的解剖学讲座。采集了卡内基13~23期的9个正常胎儿标本的完整切片图像，重建了人体、内耳、神经管和心脏的三维图像，利用多个实际图像数据合成生长过程的尝试还处于原型阶段。对困难的分析仍在进行中。该系统是在NIH图像软件的基础上进行了几次修改。