The Development and The Clinical Application of The Total Respiratory Center Function Test

全呼吸中枢功能测试的发展及临床应用

• 批准号: 07557320
• 负责人: KAMBE Masayuki
• 金额: $ 1.15万
• 依托单位: HIROSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07557320/
• 关键词: P0.1; RESPIRATORY CENTER; RESPIRATORY CONTROL; AIRWAY OCCLUSION PRESSURE; 呼吸反射テスト; 機械的受容器; 化学受容器; 呼吸中枢機能; 気道抵抗; 胸郭抵抗; 呼気NOガス; 睡眠時無呼吸症候群

We developed the new automatic machine to measure the respiratory functions which is in brain stem.This machine is composed two manometers to measure the airway occlusion pressure and the air flow of mouth included computer tips and one recorder.The principle of this machine is due to the inspiratory phase of breath is activated by N.Vagus from the respiratory center.We know already the respiratory center controls the breath based on the change of inter pressure of chest wall which can moves the lungs.By using of this new machine, we could analyze airway occlusion pressure duaring full inspiratory phase, P<@D20.1@>D2 (airway occlusion pressure at 0.1 secounds) and breath curves. So, we could analyze not only P<@D20.1@>D2 but the switch mechanism between inhale and exhale of breath among patients with some respiratory diseases. Specially, we could have an interesting result P<@D20.1@>D2 of non-attached bronchial asthma cases (28.0(]SY.+-。[)7.5mmH<@D22@>D2o) is more than P<@D20.1@>D2 of normal cases (17.6(]SY.+-。[)4.7mmH<@D22@>D2o). Although we must study the mechanisms of increasing of P<@D20.1@>D2 of non-attached bronchial asthma cases, we believe this machine is useful for patients with respiratory diseases.

我们研制了一种新型的脑干呼吸功能自动测量仪。该仪器由两个测量气道阻塞压力和口腔气流的压力计和一个记录仪组成。该仪器的原理是由于呼吸的吸气相是由呼吸中枢迷走神经激活的。我们已经知道呼吸中枢根据这种变化来控制呼吸利用该仪器可分析全吸气相气道阻塞压、0.1秒气道阻塞压（P<@D20.1@>D2）及呼吸曲线。因此，我们不仅可以分析P<@D20.1@>D2，而且可以分析某些呼吸系统疾病患者吸气与呼气之间的转换机制。特别是，我们可以得到一个有趣的结果，即非附属支气管哮喘病例的P<@D20.1@>D2（28.0（]SY.+-. D_（20）7.5mmH（D_（22））大于正常人P_（20.1）D_（20）17.6（SY. ±. D_（22）= 4.7mmH（D_（22））。虽然我们必须研究非附着性支气管哮喘病例P<@D20.1@>D2增加的机制，但我们相信这台机器对呼吸道疾病患者很有用。

项目成果

木村俊樹: "生理 ポリソムノグラフィー" Laboratory and Clinical Practice. 13. 20-22 (1995)

Toshiki Kimura：“生理性多导睡眠图”实验室和临床实践。13. 20-22 (1995)。

神辺眞之: "日常初期診療における臨床検査の使い方-呼吸器疾患-" 日本臨床病理学会, 18 (1995)

Masayuki Kannabe：“临床测试在日常初始治疗中的应用 - 呼吸系统疾病 -”日本临床病理学会，18（1995）

神辺眞之: "臨床検査ガイド'95(動脈血ガス関係)" 文光堂, 1-43 (1995)

Masayuki Kannabe：“临床测试指南 95（动脉血气相关）”Bunkodo，1-43 (1995)

T.Kimura: "Study on Circulation Status of Sleep Apnea Model" Journal of Japan Chest Diseases. 33,1. 3-9 (1995)

T.Kimura：“睡眠呼吸暂停模型的循环状态研究”日本胸部疾病杂志。

M.Kambe, T.Kimura: "Arterial Blood Gas" Standard Clinical Laborstory Guid'97. 215-219 (1997)

M.Kambe、T.Kimura：“动脉血气”标准临床实验室指南97。