Evaluation for action mechanism of Alpha2-agonist dexmedetomidine to respiratory center in medulla

α2激动剂右美托咪定对延髓呼吸中枢的作用机制评价

• 批准号: 19591821
• 负责人: TAKEDA Shinhiro
• 金额: $ 2.33万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591821/
• 关键词: 呼吸中枢; デクスメデトミジン; 呼吸性ニューロン

I administer dexmedetomidine which is the experimental group of this study and, with a rat brainstem spinal cord preparation, investigate the activity of the respiratory center. It is perfusion in the artificial cerebrospinal fluid which the specimen rises to perfusion tank, and was saturated with 95%O_2, 5% CO_2. As a breathing of the respiratory neuron activity output monitor, it is recorded inspiratory activity with an absorption electrode by a C4 ventral root. I administer dexmedetomidine in perfusion liquid and record the activity characteristics output of the breathing when respiratory depression and a breathing change occur-related neuron continually. As for the result, respiratory neuron activity was depressed dose-dependency by dexmedetomidine. However, the clear influence was not recognized in activity characteristics of the respiratory neuron by the general clinical use density. As for the restraint of the breathing in the high density-related neuron activity, indirect influence by the stimulation of the alpha-adrenoreceptor was suggested, and it seemed that there was little direct influence of dexmedetomidine to the respiratory neuron in the medulla.

我使用右美托咪定，这是这项研究的试验组，并用大鼠脑干脊髓准备，研究呼吸中枢的活动。标本升至灌注箱的人工脑脊液中灌流，浸泡在95%O_2、5%CO_2中，作为呼吸神经元活动输出监测器，由C4腹根用吸收电极记录吸气活动。我在灌流液中加入右旋美托咪定，记录呼吸抑制和呼吸变化相关神经元持续出现时呼吸的活动特征输出。结果表明，右美托咪定对呼吸神经元活性有剂量依赖性抑制作用。但一般临床应用浓度对呼吸神经元活动特性的影响不明显。至于呼吸对高密度相关神经元活动的抑制，提示刺激α-肾上腺素受体对呼吸活动有间接影响，而右旋美托咪定对延髓呼吸神经元的直接影响似乎不大。

项目成果

Efficacy of dexmedetomidine in patients with non-invasive ventilation: a preliminary study.

右美托咪定对无创通气患者的疗效：初步研究。

• 发表时间: 2008
• 期刊: Anesth Analg 107巻
• 作者: Akada S;Takeda S;et al.
• 通讯作者: et al.

デクスメデトミジンの人工呼吸管理における応用

右美托咪定在机械通气管理中的应用

• 发表时间: 2009
• 作者: Kubo;H.;Kotani;M.;Yamamoto;Y.;Hazato;T.;竹田晋浩
• 通讯作者: 竹田晋浩

Future articles. Dexmedetomidine、呼吸管理への応用

未来的文章。右美托咪定在呼吸管理中的应用

• 发表时间: 2007
• 期刊: Anesthesia 21 century 9巻
• 作者: Akada S;Takeda S;et al;竹田晋浩
• 通讯作者: 竹田晋浩

Postoperative Intensive Care Unit Drug Fever Caused by Dexmedetomidine

• DOI: 10.1213/ane.0b013e31819f1985
• 发表时间: 2009-05-01
• 期刊: ANESTHESIA AND ANALGESIA
• 影响因子: 5.7
• 作者: Okabe, Tadashi;Takeda, Shinhiro;Sakamoto, Atsuhiro
• 通讯作者: Sakamoto, Atsuhiro

人工呼吸良法における30の謎:人工呼吸中の鎮静は是か非か

良好人工呼吸的30个谜团：人工呼吸时镇静是对还是错？

• 发表时间: 2008
• 作者: 荘園 雅子;他;竹田晋浩
• 通讯作者: 竹田晋浩