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The development of the high-performance resin for medical use by using the multi-block copolymer of aramid and silicone

使用芳纶和有机硅多嵌段共聚物开发高性能医疗用树脂

基本信息

批准号：
07558257
负责人：
SERIZAWA Takeshi
金额：
$ 1.22万
依托单位：
Kagoshima University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1997
项目状态：
已结题

项目摘要

We have been studying the possible use of aramid-silicone resins (PAS) as a biomedical polymer throughout this project. In this year, the detailed investigation of the characterization and functionality of PAS were done by studying mechanical properties, thermo-mechanical properties, oxygen permeability, and blood compatibility. The results are as follows. The oxygen permeation properties of PAS membranes were investigated using the gas-liquid system. It became clear that the boundary layr resistance of the PAS membrane was effected by the hydrodynamic parameter rater than its silicone content. PAS mambrane showed the very low boundary layr resistance than silicone rubber. The low boundary layr resistance and the fairly high tensile strength of the PAS membrane enables to provide the high oxygen permeable membranes in practical applications such as an artificial lung. The surface structures of PAS membranes were characterized by angular-dependent X-ray photoelectron spectroscopy (XPS), static secondary ion mass spectrometry (SSIMS), and transmission electron microscopy (TEM). The results of XPS measurement showed that the surface concentration of the silicone segment was much higher than that in bulk. In particular, the chemical composition of the outer-most surface of the PAS films that contained over 24 wt% silicone were almost the same as that of silicone rubber. The results of SSIMS measurement and TEM observation showed the same results. It comes clear that the outermost surfaces of all of the PAS films were found to be completely covered with silicone segment even the silicone content was very low (8 wt%) in bulk. The surface enrichment of the silicone segment could be confirmed by TEM observation as well as the micro-domain stuctures in bulk. From these results, we would conclude that PAS has ability to become a high perfomance resin for medical use such as artificial lung, antithrombogenic coating, and alternative use of silicone rubber.

在整个项目中，我们一直在研究芳纶-硅树脂（PAS）作为生物医学聚合物的可能用途。在这一年里，通过研究PAS的机械性能、热机械性能、氧渗透性和血液相容性，对PAS的表征和功能进行了详细的研究。结果如下：采用气液体系研究了PAS膜的透氧性能。结果表明，影响聚丙烯腈膜边界层阻力的主要因素是水动力参数，而非有机硅含量。PAS膜的边界层电阻比硅橡胶低。PAS膜具有较低的边界层阻力和较高的抗拉强度，可在人工肺等实际应用中提供高透氧膜。采用角相关x射线光电子能谱（XPS）、静态二次离子质谱（SSIMS）和透射电子显微镜（TEM）对PAS膜的表面结构进行了表征。XPS测量结果表明，硅酮段的表面浓度远高于体块。特别是，含有超过24%有机硅的PAS膜的最外表面的化学成分与硅橡胶的化学成分几乎相同。sims测量结果与TEM观察结果一致。很明显，所有PAS薄膜的最外层表面都被硅树脂片完全覆盖，即使硅树脂含量很低（8 wt%）。通过TEM观察和块状微畴结构可以证实硅酮段的表面富集。从这些结果，我们可以得出结论，PAS有能力成为医疗用途的高性能树脂，如人工肺、抗血栓形成涂层和硅橡胶的替代用途。