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PERITONEAL MASS TRANSFER ENHANCEMENT WITH APPLICATION OF ULTRASOUND

应用超声波增强腹膜传质

基本信息

批准号：
07650962
负责人：
YAMASHITA Akihiro C.
金额：
$ 1.34万
依托单位：
Kyushu Institute of Technology at Iizuka
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07650962/
关键词：
Ultrasonic cleaner Peritoneal dialysis Mass transfer rate Blood flow rate Renal failure Ultrasound 拡散

项目摘要

Ultrasound was used to enhance the rate of peritoneal mass transfer for the success of partially intermittent peritoneal dialysis, i, e., Nightly Peritoneal Dialysis (NPD) and Day-time Ambulatory Peritoneal Dialysis (DAPD). Rates of peritoneal mass transfer for urea-nitrogen and creatinine were enhanced in significant level with applying ultrasound ; however, no significant difference was found in degree of enhancement between urea and creatinine. The enhancement was evaluated by the peritoneal dialysance and rates of enhancement were 106,159,113, and 83% for urea-nitrogen and 130,149,112, and 94% for creatinine by application of ultrasound of 0,28,45, and 100 kHz, respectively. From these results, the rate of peritoneal mass transfer enhancement seemed to be dependent on frequency of the ultrasound.Control peritoneal mass transfer experiments without use of ultrasound were performed before and after the experiment with ultrasound (trial experiment). Results showed that the rate found in the second control experiment was almost identical to that found in the trial experiment. These findings should suggest that the peritoneal mass transfer migiht have been irreversibly enhanced with ultrasound as long as it is evaluated in a short period of time.In vitro permeation experiments were also performed with the parietal peritoneum taken from a rabbit. The rates of enhancement were 162 and 149% for creatinine by application of ultrasound of 28 and 45 kHz, respectively. Then rates of peritoneal mass transfer enhancement in vitro were also dependent on frequency of the ultrasound, which corresponded well with experimental results obtained in vivo.From these observations, it would be concluded that the observed enhancement in peritoneal mass transfer by application of ultrasound should at least partially be caused by irreversible increase of permeability of the peritoneal membrane.

超声用于增强腹膜传质速率以成功进行部分间歇性腹膜透析，即，夜间腹膜透析（NPD）和日间非卧床腹膜透析（DAPD）。应用超声后，尿素氮和肌酐的腹膜传质速率显著增强，但尿素和肌酐的增强程度无显著差异。以腹膜透析率评价增强效果，0、28、45、100 kHz超声对尿素氮的增强率分别为106、159、113、83%，对肌酐的增强率分别为130、149、112、94%。从这些结果来看，腹膜传质增强的速率似乎取决于超声波的频率。在超声波实验之前和之后进行了不使用超声波的对照腹膜传质实验（试验实验）。结果表明，在第二次对照实验中发现的比率与在试验实验中发现的比率几乎相同。这些结果表明，只要在短时间内进行评价，超声波可能不可逆地促进腹膜的物质传递。我们还用家兔壁层腹膜进行了体外渗透实验。应用28和45 kHz超声时，肌酐的增强率分别为162%和149%。然后在体外的腹膜传质增强率也依赖于频率的超声波，这与实验结果在vivo.From这些意见，可以得出结论，观察到的增强腹膜传质应用超声波应至少部分是由于腹膜的渗透性不可逆的增加。