連続フロー法核磁気共鳴装置の開発と分子ダイナミックスへの利用

一个简单的流程系统与液体色谱法已经开发出来，并在个人计算机中编译了核磁共振数据，用于分析新的复合体。这些研究项目已被利用动态方法完成。（1）对1-萘二亚胺二溴胺给予二苯并-苯杂的新反应已被澄清，并对四个异构体进行核磁共振识别。基于获得的结果，已知的Ullmann-Ankersmit反应是正确的，以及[a. j.]异构体有一个选择性的准备. 2）由于伽马射线在与DNA突变的关系中对皮质酸进行了调查。动力学也已应用于MR对比剂的新开发。3）目前的方法已经有效地用于新聚合物的富衍生物复杂特性的分析，以及用于电致发光元素的terphenyl hyeterocyclics。4）在海塞大学的Shimane大学第八年被强迫将我们改变实验方法的一部分，因为液体色谱法不再可用。一个新项目是对科尔比-施密特反应的研究，长期以来一直未解决[苯甲酸-二氧化碳]复合体。动态核磁共振在没有任何怀疑的情况下提供了复杂性，并确定了结构。

A simple flow system in combination with liquid-chromatography has been developed, and NMR data compiled in the personal computer have been useful for analyzing new complex spectra. Thus various research projects have been accomplished using a dynamic method.1) A new reaction of 1-naphthyliminodimagnesium dibromide to give dibenzo-phenazine was clarified y the NMR identification of four isomers. Based on the result obtained, the known Ullmann-Ankersmit reaction has been corrected, and a selective preparation of the [a.j] isomer has been found.2) The protective action of ascorbic acid against radicals caused by gamma-ray has been investigated in the relation with DNA mutation. The dynamics have also been applied to new developements of MR contrast agent.3) The present method has been effectively used for the analysis of complex spectra of furan derivatives for new polymer and, of terphenyl heterocyclics for electroluminescence elements.4) The transferring to Shimane University in Heisei 8th year forced us to change a part of experimental methods, since no liquid chromatography was available for use. One of new projects was the study on the [phenolate・CO2] complex in the Kolbe-Schmitt reaction unsolved for long time. The dynamic NMR has proved the complex without any doubt, and determined the structure.