Hyperactive endogenous retroviruses and their impact on the koala genome

高活性内源性逆转录病毒及其对考拉基因组的影响

• 批准号: DP240102085
• 负责人: A/Prof Keith Chappell
• 金额: $ 41.04万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-02-05 至 2027-02-04
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102085
• 关键词: Hyperactive; endogenous; retroviruses; their; impact

Koala populations are in steep decline with the ubiquitous koala retrovirus (KoRV) strongly linked with disease. KoRV and other less studied endogenous retrovirus (ERVs) are extremely active within the genome of koalas to a level never observed in any other vertebrate genome. This study will map ERV integration sites within koalas from across their geographic range country and use long-read genomics approaches to understand the link between KoRV and other ERVs, the impact on koala caused by dramatic genomic rewiring, and the mechanisms of genomic immunity which supress ERV activity and mitigate disease. Findings will provide insights into the ongoing arms race between virus and host and inform conservation of an iconic species.

由于无处不在的考拉逆转录病毒（KoRV）与疾病密切相关，考拉数量急剧下降。 KoRV 和其他研究较少的内源性逆转录病毒 (ERV) 在考拉基因组中极其活跃，达到了在任何其他脊椎动物基因组中从未观察到的水平。这项研究将绘制来自不同地理分布国家的考拉体内的 ERV 整合位点，并使用长读基因组学方法来了解 KoRV 和其他 ERV 之间的联系、显着的基因组重连对考拉造成的影响，以及抑制 ERV 活性和减轻疾病的基因组免疫机制。研究结果将为病毒与宿主之间正在进行的军备竞赛提供深入见解，并为标志性物种的保护提供信息。